Polygenic risk scores predict diabetes complications and their response to intensive blood pressure and glucose control
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064190%3A_____%2F21%3AN0000046" target="_blank" >RIV/00064190:_____/21:N0000046 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/21:10429444
Result on the web
<a href="http://dx.doi.org/10.1007/s00125-021-05491-7" target="_blank" >http://dx.doi.org/10.1007/s00125-021-05491-7</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00125-021-05491-7" target="_blank" >10.1007/s00125-021-05491-7</a>
Alternative languages
Result language
angličtina
Original language name
Polygenic risk scores predict diabetes complications and their response to intensive blood pressure and glucose control
Original language description
ims/hypothesis Type 2 diabetes increases the risk of cardiovascular and renal complications, but early risk prediction could lead to timely intervention and better outcomes. Genetic information can be used to enable early detection of risk. Methods We developed a multi-polygenic risk score (multiPRS) that combines ten weighted PRSs (10 wPRS) composed of 598 SNPs associated with main risk factors and outcomes of type 2 diabetes, derived from summary statistics data of genome-wide association studies. The 10 wPRS, first principal component of ethnicity, sex, age at onset and diabetes duration were included into one logistic regression model to predict micro- and macrovascular outcomes in 4098 participants in the ADVANCE study and 17,604 individuals with type 2 diabetes in the UK Biobank study. Results The model showed a similar predictive performance for cardiovascular and renal complications in different cohorts. It identified the top 30% of ADVANCE participants with a mean of 3.1-fold increased risk of major micro- and macrovascular events (p = 6.3 x 10(-21) and p = 9.6 x 10(-31), respectively) and a 4.4-fold (p = 6.8 x 10(-33)) higher risk of cardiovascular death. While in ADVANCE overall, combined intensive blood pressure and glucose control decreased cardiovascular death by 24%, the model identified a high-risk group in whom it decreased the mortality rate by 47%, and a low-risk group in whom it had no discernible effect. High-risk individuals had the greatest absolute risk reduction with a number needed to treat of 12 to prevent one cardiovascular death over 5 years. Conclusions/interpretation This novel multiPRS model stratified individuals with type 2 diabetes according to risk of complications and helped to target earlier those who would receive greater benefit from intensive therapy.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30201 - Cardiac and Cardiovascular systems
Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
DIABETOLOGIA
ISSN
0012-186X
e-ISSN
1432-0428
Volume of the periodical
64
Issue of the periodical within the volume
9
Country of publishing house
US - UNITED STATES
Number of pages
14
Pages from-to
2012-2025
UT code for WoS article
000669749700001
EID of the result in the Scopus database
2-s2.0-85109288365