Revisiting matrix metalloproteinase 12: its role in pathophysiology of asthma and related pulmonary diseases
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064190%3A_____%2F21%3AN0000109" target="_blank" >RIV/00064190:_____/21:N0000109 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/21:10425700
Result on the web
<a href="http://dx.doi.org/10.1097/MCP.0000000000000743" target="_blank" >http://dx.doi.org/10.1097/MCP.0000000000000743</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1097/MCP.0000000000000743" target="_blank" >10.1097/MCP.0000000000000743</a>
Alternative languages
Result language
angličtina
Original language name
Revisiting matrix metalloproteinase 12: its role in pathophysiology of asthma and related pulmonary diseases
Original language description
Purpose of review Matrix metalloproteinases (MMPs) are a family of over 20 zinc-dependent proteases with different biological and pathological activities, and many have been implicated in several diseases. Although nonselective MMP inhibitors are known to induce serious side-effects, targeting individual MMPs may offer a safer therapeutic potential for several diseases. Hence, we provide a concise overview on MMP-12, given its association with pulmonary diseases, including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis, and other progressive pulmonary fibrosis (PPF), which may also occur in coronavirus disease 2019. Recent findings In asthma, COPD, and PPF, increased MMP-12 levels have been associated with inflammation and/or structural changes within the lungs and negatively correlated with functional parameters. Increased pulmonary MMP-12 levels and MMP-12 gene expression have been related to disease severity in asthma and COPD. Targeting MMP-12 showed potential in animal models of pulmonary diseases but human data are still very scarce. Although there may be a potential role of MMP-12 in asthma, COPD and PPF, several pathophysiological aspects await elucidation. Targeting MMP-12 may provide further insights into MMP-12 related mechanisms and how this translates into clinical outcomes; this warrants further research.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30203 - Respiratory systems
Result continuities
Project
—
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
CURRENT OPINION IN PULMONARY MEDICINE
ISSN
1070-5287
e-ISSN
1531-6971
Volume of the periodical
27
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
54-60
UT code for WoS article
000612723200009
EID of the result in the Scopus database
2-s2.0-85097211287