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Revisiting matrix metalloproteinase 12: its role in pathophysiology of asthma and related pulmonary diseases

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064190%3A_____%2F21%3AN0000109" target="_blank" >RIV/00064190:_____/21:N0000109 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11110/21:10425700

  • Result on the web

    <a href="http://dx.doi.org/10.1097/MCP.0000000000000743" target="_blank" >http://dx.doi.org/10.1097/MCP.0000000000000743</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1097/MCP.0000000000000743" target="_blank" >10.1097/MCP.0000000000000743</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Revisiting matrix metalloproteinase 12: its role in pathophysiology of asthma and related pulmonary diseases

  • Original language description

    Purpose of review Matrix metalloproteinases (MMPs) are a family of over 20 zinc-dependent proteases with different biological and pathological activities, and many have been implicated in several diseases. Although nonselective MMP inhibitors are known to induce serious side-effects, targeting individual MMPs may offer a safer therapeutic potential for several diseases. Hence, we provide a concise overview on MMP-12, given its association with pulmonary diseases, including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis, and other progressive pulmonary fibrosis (PPF), which may also occur in coronavirus disease 2019. Recent findings In asthma, COPD, and PPF, increased MMP-12 levels have been associated with inflammation and/or structural changes within the lungs and negatively correlated with functional parameters. Increased pulmonary MMP-12 levels and MMP-12 gene expression have been related to disease severity in asthma and COPD. Targeting MMP-12 showed potential in animal models of pulmonary diseases but human data are still very scarce. Although there may be a potential role of MMP-12 in asthma, COPD and PPF, several pathophysiological aspects await elucidation. Targeting MMP-12 may provide further insights into MMP-12 related mechanisms and how this translates into clinical outcomes; this warrants further research.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30203 - Respiratory systems

Result continuities

  • Project

  • Continuities

    V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Others

  • Publication year

    2021

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    CURRENT OPINION IN PULMONARY MEDICINE

  • ISSN

    1070-5287

  • e-ISSN

    1531-6971

  • Volume of the periodical

    27

  • Issue of the periodical within the volume

    1

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    7

  • Pages from-to

    54-60

  • UT code for WoS article

    000612723200009

  • EID of the result in the Scopus database

    2-s2.0-85097211287