Association of circulating short chain fatty acid levels with colorectal adenomas and colorectal cancer
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064190%3A_____%2F21%3AN0000113" target="_blank" >RIV/00064190:_____/21:N0000113 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/21:10440674 RIV/68378041:_____/21:00560420
Result on the web
<a href="http://dx.doi.org/10.1016/j.clnesp.2021.09.740" target="_blank" >http://dx.doi.org/10.1016/j.clnesp.2021.09.740</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.clnesp.2021.09.740" target="_blank" >10.1016/j.clnesp.2021.09.740</a>
Alternative languages
Result language
angličtina
Original language name
Association of circulating short chain fatty acid levels with colorectal adenomas and colorectal cancer
Original language description
Background & aims: Short chain fatty acid (SCFAs) are bacterially derived metabolites suggested to have protective roles against colorectal cancer (CRC) development. However, there is sparse evidence from epidemiological studies in this context. Here, we assessed whether circulating SCFA concentrations varied in patients with colorectal adenomas (CRA) and CRC. Methods: Levels of seven SCFAs were extracted from plasma samples and determined by gas chromatography for 213 individuals from Ireland and the Czech Republic (CRC, n = 84; CRA, n = 66; controls, n = 63). Results: In the Irish CRA/CRC cohort, only levels of 2-MethylButyric acid were significantly higher in cancers compared to the adenoma and control groups (p-values = 0.016 and 0.043). Using regression analysis, we observed that levels of Acetic and Propionic acid were associated with an increased CRC risk in the Czech cohort (Odd Ratio (OR): 1.02; 95% Confidence interval (CI): 1.00-1.03; OR: 1.29; 95% CI: 1.05 -1.59, respectively), while i-Valeric and Valeric acid levels were associated with a decreased cancer risk (OR: 0.92; 95% CI: 0.86-0.99; OR: 0.67; 95% CI: 0.44-1.00). In the Irish cohort, levels of SCFAs were not associated with CRC risk. Conclusions: The association with colorectal neoplasia varied between the studied SCFAs. Future studies need to confirm these findings and address the mechanism of how these acids may promote or prevent colorectal carcinogenesis. (C) 2021 The Author(s). Published by Elsevier Ltd on behalf of European Society for Clinical Nutrition and Metabolism.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30308 - Nutrition, Dietetics
Result continuities
Project
<a href="/en/project/GA20-03997S" target="_blank" >GA20-03997S: Microbial metabolites and dietary factors influencing genome and epigenome in colorectal cancer development</a><br>
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
CLINICAL NUTRITION ESPEN
ISSN
2405-4577
e-ISSN
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Volume of the periodical
46
Issue of the periodical within the volume
297-304
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
8
Pages from-to
297-304
UT code for WoS article
000757020900040
EID of the result in the Scopus database
2-s2.0-85117707788