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Association of circulating short chain fatty acid levels with colorectal adenomas and colorectal cancer

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064190%3A_____%2F21%3AN0000113" target="_blank" >RIV/00064190:_____/21:N0000113 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11110/21:10440674 RIV/68378041:_____/21:00560420

  • Result on the web

    <a href="http://dx.doi.org/10.1016/j.clnesp.2021.09.740" target="_blank" >http://dx.doi.org/10.1016/j.clnesp.2021.09.740</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.clnesp.2021.09.740" target="_blank" >10.1016/j.clnesp.2021.09.740</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Association of circulating short chain fatty acid levels with colorectal adenomas and colorectal cancer

  • Original language description

    Background & aims: Short chain fatty acid (SCFAs) are bacterially derived metabolites suggested to have protective roles against colorectal cancer (CRC) development. However, there is sparse evidence from epidemiological studies in this context. Here, we assessed whether circulating SCFA concentrations varied in patients with colorectal adenomas (CRA) and CRC. Methods: Levels of seven SCFAs were extracted from plasma samples and determined by gas chromatography for 213 individuals from Ireland and the Czech Republic (CRC, n = 84; CRA, n = 66; controls, n = 63). Results: In the Irish CRA/CRC cohort, only levels of 2-MethylButyric acid were significantly higher in cancers compared to the adenoma and control groups (p-values = 0.016 and 0.043). Using regression analysis, we observed that levels of Acetic and Propionic acid were associated with an increased CRC risk in the Czech cohort (Odd Ratio (OR): 1.02; 95% Confidence interval (CI): 1.00-1.03; OR: 1.29; 95% CI: 1.05 -1.59, respectively), while i-Valeric and Valeric acid levels were associated with a decreased cancer risk (OR: 0.92; 95% CI: 0.86-0.99; OR: 0.67; 95% CI: 0.44-1.00). In the Irish cohort, levels of SCFAs were not associated with CRC risk. Conclusions: The association with colorectal neoplasia varied between the studied SCFAs. Future studies need to confirm these findings and address the mechanism of how these acids may promote or prevent colorectal carcinogenesis. (C) 2021 The Author(s). Published by Elsevier Ltd on behalf of European Society for Clinical Nutrition and Metabolism.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30308 - Nutrition, Dietetics

Result continuities

  • Project

    <a href="/en/project/GA20-03997S" target="_blank" >GA20-03997S: Microbial metabolites and dietary factors influencing genome and epigenome in colorectal cancer development</a><br>

  • Continuities

    V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Others

  • Publication year

    2021

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    CLINICAL NUTRITION ESPEN

  • ISSN

    2405-4577

  • e-ISSN

  • Volume of the periodical

    46

  • Issue of the periodical within the volume

    297-304

  • Country of publishing house

    NL - THE KINGDOM OF THE NETHERLANDS

  • Number of pages

    8

  • Pages from-to

    297-304

  • UT code for WoS article

    000757020900040

  • EID of the result in the Scopus database

    2-s2.0-85117707788