SARS-CoV-2-related MIS-C: A key to the viral and genetic causes of Kawasaki disease?
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064190%3A_____%2F21%3AN0000143" target="_blank" >RIV/00064190:_____/21:N0000143 - isvavai.cz</a>
Alternative codes found
RIV/00064203:_____/21:10428049 RIV/00216208:11130/21:10428049
Result on the web
<a href="https://doi.org/10.1084/jem.20210446" target="_blank" >https://doi.org/10.1084/jem.20210446</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1084/jem.20210446" target="_blank" >10.1084/jem.20210446</a>
Alternative languages
Result language
angličtina
Original language name
SARS-CoV-2-related MIS-C: A key to the viral and genetic causes of Kawasaki disease?
Original language description
Multisystem inflammatory syndrome in children (MIS-C) emerged in April 2020 in communities with high COVID-19 rates. This new condition is heterogenous but resembles Kawasaki disease (KD), a well-known but poorly understood and clinically heterogenous pediatric inflammatory condition for which weak associations have been found with a myriad of viral illnesses. Epidemiological data clearly indicate that SARS-CoV-2 is the trigger for MIS-C, which typically occurs about 1 mo after infection. These findings support the hypothesis of viral triggers for the various forms of classic KD. We further suggest that rare inborn errors of immunity (IEIs) altering the immune response to SARS-CoV-2 may underlie the pathogenesis of MIS-C in some children. The discovery of monogenic IEIs underlying MIS-C would shed light on its pathogenesis, paving the way for a new genetic approach to classic KD, revisited as a heterogeneous collection of IEIs to viruses.
Czech name
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Czech description
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Classification
Type
J<sub>SC</sub> - Article in a specialist periodical, which is included in the SCOPUS database
CEP classification
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OECD FORD branch
30209 - Paediatrics
Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Experimental Medicine
ISSN
0022-1007
e-ISSN
1540-9538
Volume of the periodical
218
Issue of the periodical within the volume
6
Country of publishing house
GB - UNITED KINGDOM
Number of pages
24
Pages from-to
Article number e20210446
UT code for WoS article
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EID of the result in the Scopus database
2-s2.0-85105542114