Neutrophils mediate Th17 promotion in COVID-19 patients
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064190%3A_____%2F21%3AN0000156" target="_blank" >RIV/00064190:_____/21:N0000156 - isvavai.cz</a>
Alternative codes found
RIV/00064190:_____/20:N0000012 RIV/00216208:11110/21:10418317 RIV/00216208:11130/21:10418317 RIV/00064203:_____/21:10418317
Result on the web
<a href="https://doi.org/10.1002/JLB.4COVCRA0820-481RRR" target="_blank" >https://doi.org/10.1002/JLB.4COVCRA0820-481RRR</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/JLB.4COVCRA0820-481RRR" target="_blank" >10.1002/JLB.4COVCRA0820-481RRR</a>
Alternative languages
Result language
angličtina
Original language name
Neutrophils mediate Th17 promotion in COVID-19 patients
Original language description
From the beginning of 2020, an urgent need to understand the pathophysiology of SARS-CoV-2 disease (COVID-19), much of which is due to dysbalanced immune responses, resonates across the world. COVID-19-associated neutrophilia, increased neutrophil-to-lymphocyte ratio, aberrant neutrophil activation, and infiltration of neutrophils into lungs suggest that neutrophils are important players in the disease immunopathology. The main objective of this study was to assess the phenotypic and functional characteristics of neutrophils in COVID-19 patients, with particular focus on the interaction between neutrophils and T cells. We hypothesize that the altered functional characteristics of COVID-19 patient-derived neutrophils result in skewed Th1/Th17 adaptive immune response, thus contributing to disease pathology. The expansion of G-MDSC and immature forms of neutrophils was shown in the COVID-19 patients. In the COVID-19 neutrophil/T cell cocultures, neutrophils caused a strong polarity shift toward Th17, and, conversely, a reduction of IFNγ-producing Th1 cells. The Th17 promotion was NOS dependent. Neutrophils, the known modulators of adaptive immunity, skew the polarization of T cells toward the Th17 promotion and Th1 suppression in COVID-19 patients, contributing to the discoordinated orchestration of immune response against SARS-CoV-2. As IL-17 and other Th17-related cytokines have previously been shown to correlate with the disease severity, we suggest that targeting neutrophils and/or Th17 represents a potentially beneficial therapeutic strategy for severe COVID-19 patients.
Czech name
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Czech description
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Classification
Type
J<sub>SC</sub> - Article in a specialist periodical, which is included in the SCOPUS database
CEP classification
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OECD FORD branch
30304 - Public and environmental health
Result continuities
Project
<a href="/en/project/NU20-05-00320" target="_blank" >NU20-05-00320: Neutrophils in juvenile idiopathic arthritis: biomarkers with potential to improve clinical treatment decisions and patient care</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
JOURNAL OF LEUKOCYTE BIOLOGY
ISSN
0741-5400
e-ISSN
1938-3673
Volume of the periodical
109
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
4
Pages from-to
73-76
UT code for WoS article
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EID of the result in the Scopus database
2-s2.0-85096996071