A haemochromatosis-causing HFE mutation is associated with SARS-CoV-2 susceptibility in the Czech population

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064190%3A_____%2F22%3AN0000055" target="_blank" >RIV/00064190:_____/22:N0000055 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/23:00130381 RIV/00216208:11110/23:10452023 RIV/00216208:11120/23:43924470 RIV/00064190:_____/23:10000992 and 2 more

Result on the web

<a href="https://doi.org/10.1016/j.cca.2022.12.025" target="_blank" >https://doi.org/10.1016/j.cca.2022.12.025</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.cca.2022.12.025" target="_blank" >10.1016/j.cca.2022.12.025</a>

Result language

angličtina

Original language name

A haemochromatosis-causing HFE mutation is associated with SARS-CoV-2 susceptibility in the Czech population

Original language description

Background: Coronavirus disease (COVID-19), which is caused by the SARS-CoV-2 virus, has become a global pandemic. While susceptibility to COVID-19 is subject to several external factors, including hypertension, BMI, and the presence of diabetes, it is also genetically determined to a significant extent. Infectious agents require iron (Fe) for proper functioning. Carriers of mutations resulting in increased iron concentrations are understood to be at increased risk of COVID-19.Methods: We examined HFE genotypes associated with hereditary haemochromatosis (rs1800562 and rs1799945 SNPs) in 617 COVID-19 patients (166 asymptomatic, 246 symptomatic and 205 hospitalised survivors) and 2 559 population-based controls.Results: We found a higher frequency of the minor allele (Tyr282) of the rs1800562 polymorphism (P < 0.002) in patients compared to controls (8.5 % vs 5.5 %). Non-carriers of the minor allele were protected against SARS-Cov-2 infection (OR, 95 %CI; 0.59, 0.42-0.82). The frequency of minor allele carriers was almost identical across asymptomatic, symptomatic, and hospitalised survivors. The rs1799945 variant did not affect disease severity and its occurrence was almost identical in patients and controls (P between 0.58 and 0.84).Conclusions: In conclusion, our results indicate that presence of the rs1800562 minor allele, which is associated with hereditary haemochromatosis (thus increased levels of plasma Fe), increases susceptibility to SARS-CoV-2.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

20602 - Medical laboratory technology (including laboratory samples analysis; diagnostic technologies) (Biomaterials to be 2.9 [physical characteristics of living material as related to medical implants, devices, sensors])

Project

—

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Clinica Chimica Acta

ISSN

0009-8981

e-ISSN

1873-3492

Volume of the periodical

538

Issue of the periodical within the volume

12/2022

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

6

Pages from-to

211-215

UT code for WoS article

000923428500001

EID of the result in the Scopus database

2-s2.0-85145304911