Evaluation of presepsin as a diagnostic tool in newborns with risk of early-onset neonatal sepsis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064190%3A_____%2F22%3AN0000128" target="_blank" >RIV/00064190:_____/22:N0000128 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/23:10454193 RIV/00064203:_____/23:10454193 RIV/00064190:_____/23:10001061 RIV/00216208:11110/23:10454193 RIV/00064165:_____/23:10454193
Result on the web
<a href="https://doi.org/10.3389/fped.2022.1019825" target="_blank" >https://doi.org/10.3389/fped.2022.1019825</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fped.2022.1019825" target="_blank" >10.3389/fped.2022.1019825</a>
Alternative languages
Result language
angličtina
Original language name
Evaluation of presepsin as a diagnostic tool in newborns with risk of early-onset neonatal sepsis
Original language description
OBJECTIVES: To evaluate the efficacy of presepsin (P-SEP) as a potential biomarker of early-onset neonatal sepsis (EOS) and compare it to other routinely used markers of inflammation. To establish the cut-off values of P-SEP for EOS. STUDY DESIGN: 184 newborns were prospectively recruited between January 2018 to December 2020. Newborns >34th gestational week with suspected infection were included up to 72 h after delivery, and divided into three categories (i.e., unlikely, possible, and probable infection) based on risk factors, clinical symptoms and laboratory results. Values of plasma P-SEP were sequentially analyzed. RESULTS: Median values of P-SEP in newborns with probable infection were significantly higher compared to healthy newborns (p = 0.0000013) and unlikely infection group (p = 0.0000025). The AUC for discriminating the probable infection group from the unlikely infection group was 0.845 (95% Cl: 0.708-0.921). The diagnostic efficacy of P-SEP was highest when used in combination with IL-6 and CRP (0.97; 95% CI: 0.911-0.990). The optimal cut-off value of P-SEP was determined to be 695 ng/L. CONCLUSION: P-SEP, when combined with IL-6 and CRP, may be utilized as a negative predictive marker of EOS (NPV 97.2%, 95% CI: 93.3-101), especially in newborns at low to medium risk of infection.
Czech name
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Czech description
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Classification
Type
J<sub>SC</sub> - Article in a specialist periodical, which is included in the SCOPUS database
CEP classification
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OECD FORD branch
30209 - Paediatrics
Result continuities
Project
<a href="/en/project/NU20-07-00109" target="_blank" >NU20-07-00109: Biomarkers of endothelial injury: diagnostic significance of endothelial microvesicles, soluble proteins and microRNA in neonatal sepsis</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
FRONTIERS IN PEDIATRICS
ISSN
2296-2360
e-ISSN
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Volume of the periodical
10
Issue of the periodical within the volume
01/2023
Country of publishing house
CH - SWITZERLAND
Number of pages
12
Pages from-to
Article number 1019825
UT code for WoS article
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EID of the result in the Scopus database
2-s2.0-85146756145