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Evaluation of presepsin as a diagnostic tool in newborns with risk of early-onset neonatal sepsis

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064190%3A_____%2F22%3AN0000128" target="_blank" >RIV/00064190:_____/22:N0000128 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11130/23:10454193 RIV/00064203:_____/23:10454193 RIV/00064190:_____/23:10001061 RIV/00216208:11110/23:10454193 RIV/00064165:_____/23:10454193

  • Result on the web

    <a href="https://doi.org/10.3389/fped.2022.1019825" target="_blank" >https://doi.org/10.3389/fped.2022.1019825</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.3389/fped.2022.1019825" target="_blank" >10.3389/fped.2022.1019825</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Evaluation of presepsin as a diagnostic tool in newborns with risk of early-onset neonatal sepsis

  • Original language description

    OBJECTIVES: To evaluate the efficacy of presepsin (P-SEP) as a potential biomarker of early-onset neonatal sepsis (EOS) and compare it to other routinely used markers of inflammation. To establish the cut-off values of P-SEP for EOS. STUDY DESIGN: 184 newborns were prospectively recruited between January 2018 to December 2020. Newborns >34th gestational week with suspected infection were included up to 72 h after delivery, and divided into three categories (i.e., unlikely, possible, and probable infection) based on risk factors, clinical symptoms and laboratory results. Values of plasma P-SEP were sequentially analyzed. RESULTS: Median values of P-SEP in newborns with probable infection were significantly higher compared to healthy newborns (p = 0.0000013) and unlikely infection group (p = 0.0000025). The AUC for discriminating the probable infection group from the unlikely infection group was 0.845 (95% Cl: 0.708-0.921). The diagnostic efficacy of P-SEP was highest when used in combination with IL-6 and CRP (0.97; 95% CI: 0.911-0.990). The optimal cut-off value of P-SEP was determined to be 695 ng/L. CONCLUSION: P-SEP, when combined with IL-6 and CRP, may be utilized as a negative predictive marker of EOS (NPV 97.2%, 95% CI: 93.3-101), especially in newborns at low to medium risk of infection.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>SC</sub> - Article in a specialist periodical, which is included in the SCOPUS database

  • CEP classification

  • OECD FORD branch

    30209 - Paediatrics

Result continuities

  • Project

    <a href="/en/project/NU20-07-00109" target="_blank" >NU20-07-00109: Biomarkers of endothelial injury: diagnostic significance of endothelial microvesicles, soluble proteins and microRNA in neonatal sepsis</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2022

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    FRONTIERS IN PEDIATRICS

  • ISSN

    2296-2360

  • e-ISSN

  • Volume of the periodical

    10

  • Issue of the periodical within the volume

    01/2023

  • Country of publishing house

    CH - SWITZERLAND

  • Number of pages

    12

  • Pages from-to

    Article number 1019825

  • UT code for WoS article

  • EID of the result in the Scopus database

    2-s2.0-85146756145