Clinical characteristics of AATD-related COPD patients vary with age at diagnosis: data from the EARCO international registry
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064190%3A_____%2F25%3A10001382" target="_blank" >RIV/00064190:_____/25:10001382 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/25:10500076
Result on the web
<a href="https://doi.org/10.1186/s12890-025-03782-y" target="_blank" >https://doi.org/10.1186/s12890-025-03782-y</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/s12890-025-03782-y" target="_blank" >10.1186/s12890-025-03782-y</a>
Alternative languages
Result language
angličtina
Original language name
Clinical characteristics of AATD-related COPD patients vary with age at diagnosis: data from the EARCO international registry
Original language description
Background This study aims to evaluate the clinical characteristics of COPD patients with AATD according to their age at diagnosis. Methods Data was obtained from the European Alpha-1 Research Collaboration (EARCO) registry, an international prospective cohort study. AATD patients with COPD registered between February 2020 and October 2024 were analysed. Clinical charateristics were compared between groups, stratified by age of AATD diagnosis as follows; <45, 45-65 and >= 65 years. A multivariable logistic regression model explored factors associated with age at diagnosis. Results A total of 1,565 AATD-COPD patients were included, with 18.2% receiving an AATD diagnosis at age >= 65. In univariate comparisons according to diagnosis age revealed that the prevalence of patients with Pi*ZZ mutation was lower in the >= 65 age group (47.1%) compared to the 45-65 (65.5%) and < 45 (78.5%) age groups. In contrast, the prevalence of Pi*SZ and Pi*SS were higher in the >= 65 group compared to the younger age groups. The proportion of never-smokers was highest in the >= 65 group (39.5%), whereas only 15.3% of patients under 45 were never-smokers. Multivariate analysis showed that; compared to never-smokers, former smoking (OR: 0.08; 95% CI: 0.03-0.23) and current smoking (OR: 0.43; 95% CI: 0.27-0.70) were negatively associated with a diagnosis at age >= 65 in all sample. Compared to the Pi*ZZ genotype, among all sample, Pi*SS was associated with more than a 3-fold increased likelihood of diagnosis at age >= 65 and when considering only index cases Pi*SZ was associated with diagnosis age of >= 65 (OR: 2.01, 95%CI: 1.01-4.04). Among patients with the Pi*ZZ, current smoking was negatively associated (OR:0.24,95%CI: 0.13-0.47) with a diagnosis at age >= 65, whereas higher FEV1% and serum AAT levels were positively associated with later diagnosis. Conclusion Patients diagnosed at an older age had lower tobacco exposure and less severe disease. This suggests that subclinical symptoms may contribute to delays in diagnosis, as COPD features can be subtle or under-recognised until later in life. Our findings highlight the importance of considering AATD in all COPD patients, regardless of age, to avoid missed or delayed diagnose.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30203 - Respiratory systems
Result continuities
Project
—
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
BMC Pulmonary Medicine
ISSN
1471-2466
e-ISSN
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Volume of the periodical
25
Issue of the periodical within the volume
1
Country of publishing house
GB - UNITED KINGDOM
Number of pages
12
Pages from-to
nestránkováno
UT code for WoS article
001523062400004
EID of the result in the Scopus database
2-s2.0-105010547631