Hospitalisations in patients with idiopathic pulmonary fibrosis: insights from the IPF-PRO Registry and EMPIRE Registry

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064190%3A_____%2F26%3A10001476" target="_blank" >RIV/00064190:_____/26:10001476 - isvavai.cz</a>

Result on the web

<a href="https://doi.org/10.1183/23120541.00402-2025" target="_blank" >https://doi.org/10.1183/23120541.00402-2025</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1183/23120541.00402-2025" target="_blank" >10.1183/23120541.00402-2025</a>

Result language

angličtina

Original language name

Hospitalisations in patients with idiopathic pulmonary fibrosis: insights from the IPF-PRO Registry and EMPIRE Registry

Original language description

Background We used data from the European MultiPartner IPF Registry (EMPIRE) and the US Idiopathic Pulmonary Fibrosis-PRospective Outcomes (IPF-PRO) Registry to examine the frequency of hospitalisation, risk factors associated with hospitalisation, and whether hospitalisation affected 5-year mortality in patients with idiopathic pulmonary fibrosis (IPF). Methods Data from January 2015 to September 2022 in EMPIRE and from June 2014 to December 2023 in the IPF-PRO Registry were analysed. Rates of hospitalisation and death were estimated using the Kaplan-Meier method. Associations between patient characteristics at enrolment and time to hospitalisation were assessed using Cox regression. Results The EMPIRE and IPF-PRO Registry cohorts comprised 2989 and 1001 patients, respectively. Median follow-up was 36.5 months in EMPIRE and 60 months in the IPF-PRO Registry. Overall, 20.3% of patients in EMPIRE and 70.3% (28.2% over 36 months) in the IPF-PRO Registry had one or more hospitalisation during follow-up. In both registries, lower percentage predicted diffusing capacity of the lungs for carbon monoxide and use of supplemental oxygen at enrolment were associated with an increased risk of hospitalisation in multivariable models. 5-year mortality did not differ between patients who were and were not hospitalised in EMPIRE (54.3% and 53.7%, respectively) or in the IPF-PRO Registry (51.7% and 46.1%, respectively). Conclusions Data from EMPIRE and the IPF-PRO Registry demonstrate the high risk of hospitalisations and mortality among patients with IPF and suggest there may be differences across countries in risk of hospitalisation. Variability in data collection, healthcare systems and clinical practices should be considered when interpreting differences between countries. (C) The authors 2026.

Czech name

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Czech description

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Type

J_SC - Article in a specialist periodical, which is included in the SCOPUS database

CEP classification

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OECD FORD branch

30203 - Respiratory systems

Project

—

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2026

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

ERJ open research

ISSN

2312-0541

e-ISSN

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Volume of the periodical

12

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

9

Pages from-to

nestránkováno

UT code for WoS article

—

EID of the result in the Scopus database

2-s2.0-105032841408