Clinical relevance of Wilms tumor 1 gene mutations in childhood acute myeloid leukemia

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F09%3A5348" target="_blank" >RIV/00064203:_____/09:5348 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/09:5348

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Clinical relevance of Wilms tumor 1 gene mutations in childhood acute myeloid leukemia

Original language description

Mutations of WT1 gene were found in diagnostic pediatric AML samples. WT1 mutations conferred an independent poor prognostic significance WT1 mutations conferred an independent poor prognostic significance (WT1 mutated vs wild-type patients: 5-year probability of overall survival [pOS] 35% vs 66%, P = .002; probability of event-free survival 22% vs 46%, P < .001; and cumulative incidence of relapse or regression 70% vs 44%, P < .001). Patients with both a WT1 mutation and a FLT3/ITD had a dismal prognosis (5-year pOS 21%). WT1 mutations occur at a significant rate in childhood AML and are a novel independent poor prognostic marker.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

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Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2009

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Blood

ISSN

0006-4971

e-ISSN

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Volume of the periodical

113

Issue of the periodical within the volume

23

Country of publishing house

US - UNITED STATES

Number of pages

10

Pages from-to

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UT code for WoS article

000266656100038

EID of the result in the Scopus database

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