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Influence of Maternal Hyperglycaemia on Cord Blood Mononuclear Cells in Response to Diabetes-associated Autoantigens

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F09%3A5366" target="_blank" >RIV/00064203:_____/09:5366 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11130/09:5366

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Influence of Maternal Hyperglycaemia on Cord Blood Mononuclear Cells in Response to Diabetes-associated Autoantigens

  • Original language description

    Little is known how maternal hyperglycaemia influences the specific immune response of her baby. Furthermore, babies of type 1 diabetes (T1D) mothers have less risk of development T1D than babies with a T1D father. This study aimed to analyze the effectof maternal hyperglycaemia on newborns with focus on the response to diabetes-associated autoantigens. Newborns of T1D mothers split into groups according to maternal diabetes compensation during the 3rd trimester,newborns with T1D father, newborns witha mother treated for either gestational or type 2 diabetes and control newborns were studied. A prominent Th1 response (high IFN-gamma) from autoantigen stimulation was observed especially in babies of T1D fathers and also in mothers with perfect diabetes compensation. It seems that maternal 'sweet' as well as 'autoimmune environment' may both lead to lower occurrence of T1D within their offspring.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    EC - Immunology

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2009

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Scandinavian Journal of Immunology

  • ISSN

    0300-9475

  • e-ISSN

  • Volume of the periodical

    70

  • Issue of the periodical within the volume

    2

  • Country of publishing house

    NO - NORWAY

  • Number of pages

    10

  • Pages from-to

  • UT code for WoS article

    000268061600010

  • EID of the result in the Scopus database