Influence of Maternal Hyperglycaemia on Cord Blood Mononuclear Cells in Response to Diabetes-associated Autoantigens

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F09%3A5366" target="_blank" >RIV/00064203:_____/09:5366 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/09:5366
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Influence of Maternal Hyperglycaemia on Cord Blood Mononuclear Cells in Response to Diabetes-associated Autoantigens
Original language description
Little is known how maternal hyperglycaemia influences the specific immune response of her baby. Furthermore, babies of type 1 diabetes (T1D) mothers have less risk of development T1D than babies with a T1D father. This study aimed to analyze the effectof maternal hyperglycaemia on newborns with focus on the response to diabetes-associated autoantigens. Newborns of T1D mothers split into groups according to maternal diabetes compensation during the 3rd trimester,newborns with T1D father, newborns witha mother treated for either gestational or type 2 diabetes and control newborns were studied. A prominent Th1 response (high IFN-gamma) from autoantigen stimulation was observed especially in babies of T1D fathers and also in mothers with perfect diabetes compensation. It seems that maternal 'sweet' as well as 'autoimmune environment' may both lead to lower occurrence of T1D within their offspring.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EC - Immunology
OECD FORD branch
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Publication year
2009
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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