Maternal BMI Before Pregnancy, Maternal Weight Gain During Pregnancy, and Risk of Persistent Positivity for Multiple Diabetes-Associated Autoantibodies in Children With the High-Risk HLA Genotype The MIDIA study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F09%3A5458" target="_blank" >RIV/00064203:_____/09:5458 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/09:5458

Result on the web

—

DOI - Digital Object Identifier

—

Result language

angličtina

Original language name

Maternal BMI Before Pregnancy, Maternal Weight Gain During Pregnancy, and Risk of Persistent Positivity for Multiple Diabetes-Associated Autoantibodies in Children With the High-Risk HLA Genotype The MIDIA study

Original language description

To assess whether maternal BMI before pregnancy and weight gain during pregnancy predicted the risk of islet autoimmunity in genetically susceptible children. Of 46,939 newborns screened for the high-risk HLA genotype DR4-DQ8/DR3-DQ2, 1,003 were positiveand 885 were followed with serial blood samples tested for autoantibodies to insulin, GAD, and insulinoma-associated protein 2 (IA2). The end point was defined as repeated positivity for two or three autoantibodies or the onset of type I diabetes (isletautoimmunity). Thirty-six children developed islet autoimmunity, of whom 10 developed type I diabetes. Both maternal BMI >= 30 kg/m(2) before pregnancy and maternal weight gain >= 15 kg predicted the increased risk of islet autoimmunity (hazard ratio [HR] 2.5, P = 0.023, and HR 2.5, P = 0.015, respectively), independent of maternal diabetes. Maternal weight may predict risk of islet autoimmunity in offspring with a high genetic susceptibility to type 1 diabetes.

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FB - Endocrinology, diabetology, metabolism, nutrition

OECD FORD branch

—

Project

—

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2009

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Diabetes Care

ISSN

0149-5992

e-ISSN

—

Volume of the periodical

32

Issue of the periodical within the volume

10

Country of publishing house

US - UNITED STATES

Number of pages

3

Pages from-to

—

UT code for WoS article

000271004900027

EID of the result in the Scopus database

—