Fractionated Plasma Separation and Adsorption Significantly Decreases Intracranial Pressure in Acute Liver Failure: Experimental Study
Result description
The aim of the study was to determine the influence of fractionated plasma separation and absorption (FPSA) on intracranial pressure (ICP) in acute liver failure (ALF). METHODS: A surgical model of ALF in pigs (35-40 kg) was used. We compared laboratorydata and haemodynamic parameters from the ALF control group to the ALF group treated by Prometheus using ANOVA with repeated measures and grouping factors, by calculating the area under the curve, and by the Mann-Whitney rank test. RESULTS: Bilirubin levels differed significantly in favour of the FPSA treatment group. ICP values differed significantly in favour of the FPSA treatment group.The authors demonstrated that a significant decrease in ICP was found in pigs with ALF following treatment by FPSA.
Keywords
acute liver failureexperimental treatmentfractionated plasma separation and absorptionfulminant hepatic-failurealbumin dialysisextracorporeal systemsupportprometheus(r)braintransplantationmanagementdevicesmodel
The result's identifiers
Result code in IS VaVaI
Alternative codes found
RIV/00216208:11130/09:5468
Result on the web
—
DOI - Digital Object Identifier
—
Alternative languages
Result language
angličtina
Original language name
Fractionated Plasma Separation and Adsorption Significantly Decreases Intracranial Pressure in Acute Liver Failure: Experimental Study
Original language description
The aim of the study was to determine the influence of fractionated plasma separation and absorption (FPSA) on intracranial pressure (ICP) in acute liver failure (ALF). METHODS: A surgical model of ALF in pigs (35-40 kg) was used. We compared laboratorydata and haemodynamic parameters from the ALF control group to the ALF group treated by Prometheus using ANOVA with repeated measures and grouping factors, by calculating the area under the curve, and by the Mann-Whitney rank test. RESULTS: Bilirubin levels differed significantly in favour of the FPSA treatment group. ICP values differed significantly in favour of the FPSA treatment group.The authors demonstrated that a significant decrease in ICP was found in pigs with ALF following treatment by FPSA.
Czech name
—
Czech description
—
Classification
Type
Jx - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FJ - Surgery including transplantology
OECD FORD branch
—
Result continuities
Project
OVUVN200800002: Non biological supportive therapy in heavy liver trauma in experiment
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2009
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
European surgical research
ISSN
0014-312X
e-ISSN
—
Volume of the periodical
42
Issue of the periodical within the volume
4
Country of publishing house
CH - SWITZERLAND
Number of pages
6
Pages from-to
—
UT code for WoS article
000265131400005
EID of the result in the Scopus database
—
Basic information
Result type
Jx - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP
FJ - Surgery including transplantology
Year of implementation
2009