Expulsion of amplified MYCN from homogenously staining chromosomal regions in neuroblastoma cell lines after cultivation with cisplatin, doxorubicin, hydroxyurea, and vincristine

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F10%3A6219" target="_blank" >RIV/00064203:_____/10:6219 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/10:6219

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Expulsion of amplified MYCN from homogenously staining chromosomal regions in neuroblastoma cell lines after cultivation with cisplatin, doxorubicin, hydroxyurea, and vincristine

Original language description

Amplified MYCN, common in neuroblastomas, can be detected as double minutes (dmin) or homogenously staining chromosomal regions (hsr). Expulsion of amplified MYCN has only been described in dmin. We used hydroxyurea, which accelerates the expulsion of amplified genes and cytostatics used in neuroblastoma therapy, to describe MYCN amplification changes after chemotherapy. The loss of amplified MYCN copies was investigated using CGH and FISH. We found expulsion of amplified MYCN from hsr and determined the exact number of amplified MYCN copies. Our data show that expulsion of amplified MYCN genes is also possible from hsr and may be induced, not only by HU, but by other cytostatics as well.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Cancer Genetics and Cytogenetics

ISSN

0165-4608

e-ISSN

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Volume of the periodical

196

Issue of the periodical within the volume

1

Country of publishing house

US - UNITED STATES

Number of pages

9

Pages from-to

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UT code for WoS article

000277395600015

EID of the result in the Scopus database

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