The Effect of a Histone Deacetylase Inhibitor - Valproic Acid - on Nucleoli in Human Leukaemic Myeloblasts

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F10%3A6350" target="_blank" >RIV/00064203:_____/10:6350 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/10:6350 RIV/00023736:_____/10:00008777

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

The Effect of a Histone Deacetylase Inhibitor - Valproic Acid - on Nucleoli in Human Leukaemic Myeloblasts

Original language description

The present study was undertaken to provide more information on nucleolar changes induced by valproic acid in leukaemic myeloblasts at the single-cell level. For this study, RNA in nucleoli was visualized by a simple but sensitive cytochemical procedurein unfixed cytospins of short-term bone marrow cultures from patients suffering from acute myeloid leukaemia. The results clearly indicated that the nucleolar size and transformation of ?active? to ?sleeping? or ?inactive? nucleoli are convenient markersof the sensitivity and alteration of leukaemic myeloblasts produced by a histone deacetylase inhibitor, valproic acid, at the single-cell level.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Folia Biologica

ISSN

0015-5500

e-ISSN

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Volume of the periodical

56

Issue of the periodical within the volume

5

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

5

Pages from-to

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UT code for WoS article

000284254900002

EID of the result in the Scopus database

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