An Adsorptive Transfer Technique Coupled with Brdicka Reaction to Reveal the Importance of Metallothionein in Chemotherapy with Platinum Based Cytostatics

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F10%3A6388" target="_blank" >RIV/00064203:_____/10:6388 - isvavai.cz</a>

Alternative codes found

RIV/62156489:43210/10:00166514 RIV/62157124:16370/10:00002648 RIV/00216208:11130/10:6388

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

An Adsorptive Transfer Technique Coupled with Brdicka Reaction to Reveal the Importance of Metallothionein in Chemotherapy with Platinum Based Cytostatics

Original language description

The drugs based on platinum metals represent effective groups of chemotherapeutic agents. It is known that resistance of tumor cells to drugs is a frequent cause of chemotherapy failure. Platinum based drugs resistance can also be connected with increased expression of metallothionein (MT). This study aimed at investigating the interactions of MT with cisplatin or carboplatin, using the adsorptive transfer technique coupled with differential pulse voltammetry Brdicka reaction, and a comparison of results in vitro and in vivo. The results obtained from the in vitro study show a strong affinity between platinum based drugs and MT. Further, we analyzed neuroblastoma lines treated with cisplatin or carboplatin. It is clear that cisplatin-resistant and cisplatin-sensitive lines unlikely respond to the presence of cisplatin and carboplatin. Finally, we determined the level of MT in samples from rabbits and serum samples from patients with retinoblastoma treated with carboplatin.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International Journal of Molecular Science

ISSN

1422-0067

e-ISSN

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Volume of the periodical

11

Issue of the periodical within the volume

12

Country of publishing house

US - UNITED STATES

Number of pages

17

Pages from-to

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UT code for WoS article

000285708000004

EID of the result in the Scopus database

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