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Urinary transforming growth factor-beta 1 in children with obstructive uropathy

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F11%3A7032" target="_blank" >RIV/00064203:_____/11:7032 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11130/11:7032

  • Result on the web

    <a href="http://www.ncbi.nlm.nih.gov/pubmed/21382126" target="_blank" >http://www.ncbi.nlm.nih.gov/pubmed/21382126</a>

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Urinary transforming growth factor-beta 1 in children with obstructive uropathy

  • Original language description

    Aim: Obstructive uropathies (OU) in childhood constitute one of the major causes of chronic renal insufficiency. Transforming growth factor-beta 1 (TGF-beta 1) is considered to be the major fibrogenic growth factor. The aim of the present study was to investigate urinary TGF-beta 1 levels in children with obstructive and non-obstructive uropathies (NOU). Methods: This study involved 19 children with OU, 11 children with non-obstructive hydronephrosis and 21 healthy children. Urinary TGF-beta 1, proteinuria, microalbuminuria and urinary alpha 1-microglobulin were measured, and renal function was assesed. The results were statistically analyzed. Results: Mean urinary TGF-beta 1 concentrations in patients with OU were significantly higher than those withNOU (4.14 +/- 0.67 creatinine vs 1.80 +/- 1 0.24 pg/mmol creatinine, P < 0.05) and healthy controls (1.66 +/- 0.28 pg/mmol creatinine, P < 0.05). Positive correlations of urinary TGF-beta 1 concentrations with proteinuria (r = 0.87, P < 0

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FP - Other medical fields

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2011

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Nephrology

  • ISSN

    1320-5358

  • e-ISSN

  • Volume of the periodical

    16

  • Issue of the periodical within the volume

    6

  • Country of publishing house

    AU - AUSTRALIA

  • Number of pages

    4

  • Pages from-to

    595-598

  • UT code for WoS article

    000293240900009

  • EID of the result in the Scopus database