The diffusion parameters of the extracellular space are altered in focal cortical dysplasias
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F11%3A7038" target="_blank" >RIV/00064203:_____/11:7038 - isvavai.cz</a>
Alternative codes found
RIV/68378041:_____/11:00366716 RIV/00216208:11130/11:7038
Result on the web
<a href="http://www.ncbi.nlm.nih.gov/pubmed/21620932" target="_blank" >http://www.ncbi.nlm.nih.gov/pubmed/21620932</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
The diffusion parameters of the extracellular space are altered in focal cortical dysplasias
Original language description
Most hypotheses concerning the mechanisms underlying seizure activity in focal cortical dysplasia (FCD) are based on alterations in synaptic transmission and glial dysfunction. However, neurons may also communicate by extrasynaptic transmission, which was recently found to affect epileptiform activity under experimental conditions and which is mediated by the diffusion of neuroactive substances in the extracellular space (ECS). The ECS diffusion parameters were therefore determined using the real-time iontophoretic method in human neocortical tissue samples obtained from surgically treated epileptic patients. The obtained values of the extracellular space volume fraction and tortuosity were then correlated with the histologicaly assessed type of cortical malformation (FCD type I or II). While the extracellular volume remained unchanged (FCD l) or larger (FCD II) than in normal/control tissue, tortuosity was significantly increased in both types of dysplasia, indicating the presence of
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NS9915" target="_blank" >NS9915: Properties of the extracellular space of the epileptic neocortex - significance for the pathogenesis and diagnosis of refractory epilepsy</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Neuroscience Letters
ISSN
0304-3940
e-ISSN
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Volume of the periodical
499
Issue of the periodical within the volume
1
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
5
Pages from-to
19-23
UT code for WoS article
000292804200005
EID of the result in the Scopus database
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