Metabolic Impact of Growth Hormone Treatment in Short Children Born Small for Gestational Age
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F11%3A7170" target="_blank" >RIV/00064203:_____/11:7170 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/11:7170
Result on the web
<a href="http://www.ncbi.nlm.nih.gov/pubmed/21893941" target="_blank" >http://www.ncbi.nlm.nih.gov/pubmed/21893941</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Metabolic Impact of Growth Hormone Treatment in Short Children Born Small for Gestational Age
Original language description
Background: Growth hormone (GH) treatment in short children born small for gestational age (SGA) may result in metabolic changes with potential long-term effects. Methods: 149 short SGA children (mean birth weight 2.0 +/- 0.6 kg, age 5.5 +/- 1.5 years, height standard deviation score (SDS) -3.1 +/- 0.6) were randomised to: low-dose GH therapy (0.033 mg/kg/day) for 2 years; high-dose GH therapy (0.100 mg/kg/day) for 1 year, or mid-dose GH therapy (0.067 mg/kg/day) for 1 year. Leptin, ghrelin, insulin-like growth factor-I (IGF-I), IGF binding protein-1 (IGFBP-1), lipids, fasting blood glucose and fasting insulin were assessed at baseline, 12 and 24 months. Results: After 1 year of active treatment, GH significantly reduced serum ghrelin and increased IGF-I SDS and insulin levels. Regression analysis showed an inverse correlation between ghrelin and IGF-I SDS (p < 0.001). Leptin and IGFBP-1 also declined (both p < 0.05). Changes in insulin levels reversed upon discontinuation. Improvement
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FG - Paediatrics
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Hormone Research in Paediatrics
ISSN
1663-2818
e-ISSN
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Volume of the periodical
76
Issue of the periodical within the volume
4
Country of publishing house
CH - SWITZERLAND
Number of pages
8
Pages from-to
254-261
UT code for WoS article
000296392700006
EID of the result in the Scopus database
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