Quantitative molecular analysis in mantle cell lymphoma

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F11%3A7241" target="_blank" >RIV/00064203:_____/11:7241 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/11:7241
Result on the web
<a href="http://www.medvik.cz/link/bmc11037499" target="_blank" >http://www.medvik.cz/link/bmc11037499</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Quantitative molecular analysis in mantle cell lymphoma
Original language description
A molecular analysis has three major roles in modern oncopathology ? as an aid in the differential diagnosis, in molecular monitoring of diseases, and in estimation of the potential prognosis. In this report we review the application of the molecular analysis in a group of patients with mantle cell lymphoma (MCL). We demonstrate that detection of the cyclin D1 mRNA level is a molecular marker in 98 % of patients with MCL. Cyclin D1 quantitative monitoring is specific and sensitive for the differential diagnosis and for the molecular monitoring of the disease in the bone marrow. Moreover, the dynamics of cyclin D1 in bone marrow reflects the disease development and it predicts the clinical course. We employed the molecular analysis for a precise quantitative detection of proliferation markers, Ki-67, topoisomerase II?, and TPX2, that are described as effective prognostic factors. Using the molecular approach it is possible to measure the proliferation rate in a reproducible, standard wa
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FP - Other medical fields
OECD FORD branch
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Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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