Fertility after allogeneic haematopoietic stem cell transplantation in childhood and adolescence

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F12%3A7991" target="_blank" >RIV/00064203:_____/12:7991 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1038/bmt.2011.78" target="_blank" >http://dx.doi.org/10.1038/bmt.2011.78</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Fertility after allogeneic haematopoietic stem cell transplantation in childhood and adolescence
Original language description
Infertility is a major late effect in patients receiving haematopoietic stem cell transplantation (HSCT). The aim of this study was to determine the proportion of patients having fertility impairment after allogeneic HSCT in childhood/adolescence and toidentify the potential risk factors. Treatment and fertility data of paediatric patients with malignant and non-malignant diseases treated with allogeneic HSCT between 2000 and 2005 were collected from seven European centres. Data were obtained for 138 female and 206 male patients after a median follow-up of 6 years (range 3-12). The patients' median age was 13 years (range 4-28) at the time of HSCT and 19 (range 12-35) years at the time of the enquiry. Seven children were born to the overall group, allat term and healthy. Fertility impairment was suspected in 69% males and 83% females. Start of treatment at age >= 13 years was a risk factor in females (odds ratio (OR) 4.7; 95% confidence interval (CI), 1.5 to 14.9), whereas pre-pubert
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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