Urine and Serum Cathepsin B Concentrations in the Transitional Cell Carcinoma of the Bladder

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F12%3A8082" target="_blank" >RIV/00064203:_____/12:8082 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/12:8082
Result on the web
<a href="http://dx.doi.org/10.1002/jcla.21483" target="_blank" >http://dx.doi.org/10.1002/jcla.21483</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Urine and Serum Cathepsin B Concentrations in the Transitional Cell Carcinoma of the Bladder
Original language description
Background: It has been shown that expression and activity of lysosomal proteolytic enzymes (i.e., cathepsin B) correlate with tumor progression in various neoplasms. We investigate possible correlation of cathepsin B concentrations with grading and invasivity of tumorous bladder tissue. Method: Cathepsin B concentrations in serum and urine were measured in 40 patients (29 men, 11 women, mean age 68 years) with transitional cell carcinoma (TCC) of the bladder without metastases and in control group of 64 healthy subjects (28 men, 36 women, mean age 55 years) using commercially available enzymatic immunoassay. Concentration of cathepsin B in urine was adjusted on creatinine. Urinary creatinine in all samples was measured by enzymatic creatinase method.Patients were divided into groups according to the grading (low grading: 18 patients, high grading: 22 patients) and invasivity of the carcinoma (nonmuscle-invasive tumors: 23 patients, invasive tumors: 17 patients). Result: Concentration
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FS - Medical facilities, apparatus and equipment
OECD FORD branch
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Project
<a href="/en/project/NT11415" target="_blank" >NT11415: Activity of Cathepsine B in Patient with Bladder Cancer</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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