HLA-DRB1-DQA1-DQB1 Genotype and Frequency of Enterovirus in Longitudinal Monthly Fecal Samples from Healthy Infants

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F12%3A8106" target="_blank" >RIV/00064203:_____/12:8106 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/12:8106

Result on the web

<a href="http://www.ncbi.nlm.nih.gov/pubmed/22691100" target="_blank" >http://www.ncbi.nlm.nih.gov/pubmed/22691100</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

HLA-DRB1-DQA1-DQB1 Genotype and Frequency of Enterovirus in Longitudinal Monthly Fecal Samples from Healthy Infants

Original language description

Enterovirus infections may be involved in the etiology of type 1 diabetes (T1D), which is strongly associated with certain human leukocyte antigen (HLA) class II haplotypes. Our aim was to assess whether HLA genotypes conferring varying degrees of risk for T1D were associated with enterovirus gut infections. From the general Norwegian population, 190 healthy infants at high-risk for T1D (DR4-DQ8/DR3-DQ2), and 383 infants without this genotype were identified. Non-DR4-DQ8/DR3-DQ2 genotypes were further categorized as conferring either an increased-to-moderate risk (DR4-DQ8 or DR3-DQ2), were protective (DQB1*06:02), or were neutral (all other genotypes). A total of 4626 monthly fecal samples taken between age 3 and 12mo were tested for enterovirus RNA using real-time PCR. Enterovirus prevalence was 11.5% among high-risk children, and 12.2% in other children (adjusted odds ratio: 1.23, p = 0.12). The prevalence was 11.3% in those with increased-to-moderate risk, 13.0% in the protective gr

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EC - Immunology

OECD FORD branch

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Project

<a href="/en/project/NT11465" target="_blank" >NT11465: Selected picornaviruses in the pathogenesis of islet autoimmunity and type 1 diabetes</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Viral Immunology

ISSN

0882-8245

e-ISSN

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Volume of the periodical

25

Issue of the periodical within the volume

3

Country of publishing house

US - UNITED STATES

Number of pages

6

Pages from-to

187-192

UT code for WoS article

000305285000003

EID of the result in the Scopus database

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