High positive predictive value of PAPP-A for acute coronary syndrome diagnosis in heparin-naive patients

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F12%3A8158" target="_blank" >RIV/00064203:_____/12:8158 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/12:8158
Result on the web
<a href="http://dx.doi.org/10.1007/s11239-012-0679-9" target="_blank" >http://dx.doi.org/10.1007/s11239-012-0679-9</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
High positive predictive value of PAPP-A for acute coronary syndrome diagnosis in heparin-naive patients
Original language description
Pregnancy-associated plasma protein-A (PAPP-A) was studied as a marker of acute coronary syndrome (ACS). It has been shown that its levels are increased by heparin administration. Therefore, the aim of our study was to ascertain the diagnostic significance of PAPP-A in heparin-na < ve patients and compare it with (TnI). We prospectively studied 67 heparin-na < ve patients with acute chest pain. The patients were independently grouped according to the presence or absence of ACS. PAPP-A levels were significantly increased in ACS patients (8.6 vs. 7.3 mIU/l; P = 0.006) with high positive (95.7%) and lower negative predictive values (47.7%). In multivariate analysis, its levels were strongly predictive of a final diagnosis of ACS (OR 41.8; 95th CI 2.64-662.6; P = 0.008). The diagnostic significance of PAPP-A was not higher than TnI even within 6 h after the onset of chest pain [the area under the ROC curve (AUC) was 0.69 for PAPP-A and 0.91 for TnI, respectively; P = 0.08]. We observed no
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FA - Cardiovascular diseases including cardio-surgery
OECD FORD branch
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Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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