Randomized Double-Blind Study: Wound-Healing Effects of a Symphytum Herb Extract Cream (Symphytum x uplandicum NYMAN) in Children

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F12%3A8186" target="_blank" >RIV/00064203:_____/12:8186 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/12:8186

Result on the web

<a href="http://dx.doi.org/10.1055/s-0032-1308981" target="_blank" >http://dx.doi.org/10.1055/s-0032-1308981</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Randomized Double-Blind Study: Wound-Healing Effects of a Symphytum Herb Extract Cream (Symphytum x uplandicum NYMAN) in Children

Original language description

The wound healing effects of the topically applied preparation Traumaplant (R) containing a concentrate (10% active ingredient) from the aerial parts of medicinal comfrey (Symphytum x uplandicum NYMAN) were examined in a randomized, controlled, clinicaldouble-blind study. An otherwise identical low-dose preparation (1% active ingredient) was used as a control. The study population consisted of 108 children aged 3-12 years (n = 54/group) with fresh abrasions. A 50% healing rate was reached 0.9 days earlier with the higher than with the lower concentration cream. The difference in the healing rate (0.38 +/- 0.18/day [95% CI 0.33-0.4] vs. 0.26 +/- 0.14/day [95% CI 0.222-0.297]) was statistically significant (p = 0.0002). Physicians and children/parents both rated the efficacy of the 10% cream as significantly better than that of the control preparation (physicians' assessment after 2-3 and 7-9 days for verum vs. control: 90.7 and 92.6% vs. 55.6 and 74.0% of the healing rates were rated a

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Arzneimittel-Forschung-Drug Research

ISSN

0004-4172

e-ISSN

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Volume of the periodical

62

Issue of the periodical within the volume

6

Country of publishing house

DE - GERMANY

Number of pages

5

Pages from-to

285-289

UT code for WoS article

000307600000005

EID of the result in the Scopus database

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