The use of sodium-chloride difference and chloride-sodium ratio in the evaluation of metabolic acidosis in critically ill patients

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F12%3A8251" target="_blank" >RIV/00064203:_____/12:8251 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/12:8251

Result on the web

<a href="http://dx.doi.org/10.1007/s00431-012-1833-2" target="_blank" >http://dx.doi.org/10.1007/s00431-012-1833-2</a>

DOI - Digital Object Identifier

—

Result language

angličtina

Original language name

The use of sodium-chloride difference and chloride-sodium ratio in the evaluation of metabolic acidosis in critically ill patients

Original language description

We read the study of Kurt et al. [4] and we believe that sodium chloride difference (Diff(NaCl)) and Cl Na ratio cannot be considered as an alternative method for assessment of unmeasured anions or tissue acids (TA). Significant correlation between Cl Naratio and TA is not an unexpected result because metabolic acidosis (MAC) is generally caused either by loss of bicarbonate (insufficient renal synthesis of HCO3 compensated by an increase of Cl) or by retention of acids (chlorides remain unchanged), frequently by both. The correlation is a weak evidence that one method can replace another. The confidence interval is not specified but at first glance it is apparent that variability is too high (Fig. 1e). Cl Na ratio cannot be reliably used as a bedsidemethod as it cannot exclude the accumulation of TA in individual case. Cl Na ratio indicates only approximately whether MAC with unchanged Cl is associated with retention of acids and MAC with hyperchloremia with insufficient synthesis o

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FG - Paediatrics

OECD FORD branch

—

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

European Journal of Pediatrics

ISSN

0340-6199

e-ISSN

—

Volume of the periodical

171

Issue of the periodical within the volume

11

Country of publishing house

DE - GERMANY

Number of pages

1

Pages from-to

1719

UT code for WoS article

000310810700023

EID of the result in the Scopus database

—