Echocardiographic Evidence for Valvular Toxicity of Benfluorex: A Double-Blind Randomised Trial in Patients with Type 2 Diabetes Mellitus

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F12%3A8585" target="_blank" >RIV/00064203:_____/12:8585 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/12:8585

Result on the web

<a href="http://dx.doi.org/10.1371/journal.pone.0038273" target="_blank" >http://dx.doi.org/10.1371/journal.pone.0038273</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Echocardiographic Evidence for Valvular Toxicity of Benfluorex: A Double-Blind Randomised Trial in Patients with Type 2 Diabetes Mellitus

Original language description

At baseline, patients were 59.1+/-10.5 years old with HbA(1c) 8.3+/-0.8%, and DM duration 7.1+/-6.0 years. During the study, mean HbA(1c) significantly decreased in both groups (benfluorex: from 8.30+/-0.80 to 7.77+/-1.31 versus pioglitazone: from 8.30+/-0.80 to 7.45+/-1.30%). The last HbA(1c) value was significantly lower with pioglitazone than with benfluorex (p<0.001) and non-inferiority of benfluorex was not confirmed (p = 0.19). Among the 615 patients with assessable paired echocardiography (310 benfluorex, 305 pioglitazone), 314 (51%) had at least one morphological valvular abnormality and 515 (84%) at least one functional valvular abnormality at baseline. Emergent morphological abnormalities occurred in 8 patients with benfluorex versus 4 with pioglitazone (OR 1.99), 95% CI (0.59 to 6.69). Emergent regurgitation (new or increased by one grade or more) occurred more frequently with benfluorex (82 patients, 27%) than with pioglitazone (33 patients, 11%) (OR 2.97), 95% CI (1.91 to

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FB - Endocrinology, diabetology, metabolism, nutrition

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

PLoS One

ISSN

1932-6203

e-ISSN

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Volume of the periodical

7

Issue of the periodical within the volume

6

Country of publishing house

US - UNITED STATES

Number of pages

12

Pages from-to

1-12

UT code for WoS article

000305652700013

EID of the result in the Scopus database

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