A randomized comparison of two prophylaxis regimens and a paired comparison of on-demand and prophylaxis treatments in hemophilia A management.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F12%3A8806" target="_blank" >RIV/00064203:_____/12:8806 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/12:8806

Result on the web

<a href="http://dx.doi.org/10.1111/j.1538-7836.2011.04611.x" target="_blank" >http://dx.doi.org/10.1111/j.1538-7836.2011.04611.x</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

A randomized comparison of two prophylaxis regimens and a paired comparison of on-demand and prophylaxis treatments in hemophilia A management.

Original language description

Prophylaxis with factor (F)VIII is considered the optimal treatment for managing hemophilia A patients without inhibitors.To compare the efficacy of two prophylaxis regimens (primary outcome) and of on-demand and prophylaxis treatments (secondary outcome), and to continue the evaluation of immunogenicity and overall safety of the ADVATE Antihemophilic Factor (Recombinant), Plasma/Albumin Free Method (rAHF-PFM). Previously on-demand-treated patients aged 7-59 years (n = 66) with FVIII levels 2% received6 months of on-demand treatment and then were randomized to 12 months of either standard (20-40 IU kg(-1) every other day) or pharmacokinetic (PK)-tailored (20-80 IU kg(-1) every third day) prophylaxis, both regimens intended to maintain FVIII trough levels at or above 1%. Efficacy was evaluated in terms of annualized bleeding rates (ABRs). As subjects were first treated on-demand and then on prophylaxis, statistical comparisons between these treatments were paired.Twenty-two (33.3%) sub

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Thrombosis and Haemostasis

ISSN

1538-7933

e-ISSN

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Volume of the periodical

10

Issue of the periodical within the volume

3

Country of publishing house

GB - UNITED KINGDOM

Number of pages

9

Pages from-to

359-367

UT code for WoS article

000300876600005

EID of the result in the Scopus database

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