The Pattern of Diffusion Parameter Changes in Alzheimer's Disease, Identified by Means of Linked Independent Component Analysis

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F13%3A10196666" target="_blank" >RIV/00064203:_____/13:10196666 - isvavai.cz</a>
Alternative codes found
RIV/00159816:_____/13:00060684 RIV/00216208:11130/13:10196666
Result on the web
<a href="http://dx.doi.org/10.3233/JAD-122431" target="_blank" >http://dx.doi.org/10.3233/JAD-122431</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3233/JAD-122431" target="_blank" >10.3233/JAD-122431</a>

Result language
angličtina
Original language name
The Pattern of Diffusion Parameter Changes in Alzheimer's Disease, Identified by Means of Linked Independent Component Analysis
Original language description
Several recent studies have indicated that white matter is affected in Alzheimer's disease (AD). Diffusion tensor imaging is a tool by which the white matter microstructure can be examined in vivo, and might offer a possibility for the identification ofthe pattern of white matter disintegration in AD. In the current analysis, we made use of a novel model-free analysis approach of linked independent component analysis to identify a motif of diffusion parameter alterations exemplifying AD. Analysis of the diffusion data of 16 AD patients and 17 age-matched healthy subjects revealed six independent components, two of which demonstrated differences between the patients and controls. Component #0 was dominated by axial diffusivity, but significant alterations in fractional anisotropy and mean and radial diffusivity were also detected. Alterations were found in regions of crossing of major white matter pathways, such as forceps, corona radiata, and superior longitudinal fascicle, as well as
Czech name
—
Czech description
—

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
—

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)