The MLL recombinome of acute leukemias in 2013
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F13%3A10196703" target="_blank" >RIV/00064203:_____/13:10196703 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/13:10196703 RIV/61989592:15110/13:33145791
Result on the web
<a href="http://dx.doi.org/10.1038/leu.2013.135" target="_blank" >http://dx.doi.org/10.1038/leu.2013.135</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/leu.2013.135" target="_blank" >10.1038/leu.2013.135</a>
Alternative languages
Result language
angličtina
Original language name
The MLL recombinome of acute leukemias in 2013
Original language description
Chromosomal rearrangements of the human MLL (mixed lineage leukemia) gene are associated with high-risk infant, pediatric, adult and therapy-induced acute leukemias. We used long-distance inverse-polymerase chain reaction to characterize the chromosomalrearrangement of individual acute leukemia patients. We present data of the molecular characterization of 1590 MLL-rearranged biopsy samples obtained from acute leukemia patients. The precise localization of genomic breakpoints within the MLL gene and the involved translocation partner genes (TPGs) were determined and novel TPGs identified. All patients were classified according to their gender (852 females and 745 males), age at diagnosis (558 infant, 416 pediatric and 616 adult leukemia patients) andother clinical criteria. Combined data of our study and recently published data revealed a total of 121 different MLL rearrangements, of which 79 TPGs are now characterized at the molecular level. However, only seven rearrangements seem t
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Leukemia
ISSN
0887-6924
e-ISSN
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Volume of the periodical
27
Issue of the periodical within the volume
11
Country of publishing house
GB - UNITED KINGDOM
Number of pages
12
Pages from-to
2165-2176
UT code for WoS article
000326882500007
EID of the result in the Scopus database
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