Leukemia surfaceome analysis reveals new disease-associated features
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F13%3A10209593" target="_blank" >RIV/00064203:_____/13:10209593 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/13:10209593
Result on the web
<a href="http://dx.doi.org/10.1182/blood-2012-11-468702" target="_blank" >http://dx.doi.org/10.1182/blood-2012-11-468702</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1182/blood-2012-11-468702" target="_blank" >10.1182/blood-2012-11-468702</a>
Alternative languages
Result language
angličtina
Original language name
Leukemia surfaceome analysis reveals new disease-associated features
Original language description
A better description of the leukemia cell surface proteome (surfaceome) is a prerequisite for the development of diagnostic and therapeutic tools. Insights into the complexity of the surfaceome have been limited by the lack of suitable methodologies. Wecombined a leukemia xenograft model with the discovery-driven chemoproteomic Cell Surface Capture technology to explore the B-cell precursor acute lymphoblastic leukemia (BCP-ALL) surfaceome; 713 cell surface proteins, including 181 CD proteins, were detected through combined analysis of 19 BCP-ALL cases. Diagnostic immunophenotypes were recapitulated in each case, and subtype specific markers were detected. To identify new leukemia-associated markers, we filtered the surfaceome data set against gene expression information from sorted, normal hematopoietic cells. Nine candidate markers (CD18, CD63, CD31, CD97, CD102, CD157, CD217, CD305, and CD317) were validated by flow cytometry in patient samples at diagnosis and during chemotherapy.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Blood
ISSN
0006-4971
e-ISSN
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Volume of the periodical
121
Issue of the periodical within the volume
25
Country of publishing house
US - UNITED STATES
Number of pages
11
Pages from-to
"E149"-"E159"
UT code for WoS article
000321898500001
EID of the result in the Scopus database
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