Concentrations of MMP-9 and TIMP-1 in lip tissue and their impact on cleft lip surgery healing

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F13%3A10209799" target="_blank" >RIV/00064203:_____/13:10209799 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11120/13:43901647 RIV/00064173:_____/13:#0000295 RIV/00216208:11130/13:10209799

Result on the web

<a href="http://dx.doi.org/10.5507/bp.2012.088" target="_blank" >http://dx.doi.org/10.5507/bp.2012.088</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5507/bp.2012.088" target="_blank" >10.5507/bp.2012.088</a>

Result language

angličtina

Original language name

Concentrations of MMP-9 and TIMP-1 in lip tissue and their impact on cleft lip surgery healing

Original language description

Aim. To compare aspects of wound healing after cleft lip surgery performed within one week of age and wound healing after surgery performed within 2 - 4 months of age, especially concentrations of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinases-1 (TIMP-1) in tissue removed during surgery. Methods. 34 tissue samples (26 boys and 8 girls) were removed during surgery within one week of age (n=19) or within 2 - 4 months of age (n=15). Tissue samples were separated into epidermis, dermis and mucous membrane. Proteins were extracted in cacodylic buffer for 24 h at a temperature 2 - 8 degrees C. Total protein concentrations were examined using a modification of the Lowry method. Samples were examined using ELISA kit Amersham Biotrak Activity Assay (GE Healthcare UK) for detection of MMP-9 and TIMP-1 concentrations. Results. MMP-9: early surgery - epidermis 2.168+/-3.303 mu g/g of protein (mean+/-SD), dermis 1.251+/-1.848 mu g/g, 2 - 4 months surgery - epidermis 0

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FP - Other medical fields

OECD FORD branch

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Project

<a href="/en/project/NS10012" target="_blank" >NS10012: The Effect of Early Surgery for Cleft Lip in Neonates on Wound Healing.</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biomedical Papers

ISSN

1213-8118

e-ISSN

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Volume of the periodical

157

Issue of the periodical within the volume

4

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

4

Pages from-to

363-366

UT code for WoS article

000329091500015

EID of the result in the Scopus database

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