Effect of Donepezil in Alzheimer Disease Can Be Measured by a Computerized Human Analog of the Morris Water Maze

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F14%3A10193109" target="_blank" >RIV/00064203:_____/14:10193109 - isvavai.cz</a>

Alternative codes found

RIV/00159816:_____/14:00060941 RIV/00216208:11130/14:10193109 RIV/00216208:11150/14:10193109

Result on the web

<a href="http://www.karger.com/Article/FullText/355517" target="_blank" >http://www.karger.com/Article/FullText/355517</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1159/000355517" target="_blank" >10.1159/000355517</a>

Result language

angličtina

Original language name

Effect of Donepezil in Alzheimer Disease Can Be Measured by a Computerized Human Analog of the Morris Water Maze

Original language description

Drug development for Alzheimer disease (AD) is challenged by the success in animal models tested in the Morris water maze (MWM) and the subsequent failures to meet primary outcome measures in phase II or III clinical trials in patients. The human variantof MWM (hMWM) enables us to examine allocentric and egocentric navigation as in the MWM. Objective: It was the aim of this study to examine the utility of a computerized hMWM to assess the effects of donepezil in mild AD. Methods: Donepezil 5 mg/day wasstarted after initial hMWM testing in the treated group (n = 12), and after 28 days, the dose was increased to 10 mg/day. The performance after 3 months was compared to that of a non-treated group (n = 12). Results: Donepezil stabilized or improved thespatial navigation performance after 3 months, especially in the allocentric delayed recall subtask (p = 0.014). Conclusions: The computerized hMWM has the potential to measure the effects of donepezil in mild AD. It is a sensitive cognit

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

<a href="/en/project/ED1.100%2F02%2F0123" target="_blank" >ED1.100/02/0123: St. Anne´s University Hospital Brno - International Clinical Research Center (FNUSA-ICRC)</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neurodegenerative Diseases

ISSN

1660-2854

e-ISSN

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Volume of the periodical

13

Issue of the periodical within the volume

2-3

Country of publishing house

CH - SWITZERLAND

Number of pages

5

Pages from-to

192-196

UT code for WoS article

000330752200036

EID of the result in the Scopus database

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