Disease Activity Is an Important Factor for Indeterminate Interferon-gamma Release Assay Results in Children With Inflammatory Bowel Disease
Result description
Background:Interferon- release assay (IGRA) is widely used for screening of latent tuberculosis (TB) before and during biological therapy (BT). An indeterminate result of IGRA represents a limitation in the management of inflammatory bowel disease (IBD).Data on factors influencing IGRA results are scarce in children. The aim of the study was to identify factors influencing IGRA results in children with IBD.Methods:Seventy-two children with IBD (59 Crohn disease, 11 ulcerative colitis, 2 IBD-unclassified) indicated for BT were tested for TB infection (history, TB skin test, chest radiograph, IGRA; QuantiFERONTB Gold in tube [QFT]) and consecutively retested using QFT in 1-year intervals.Results:We recorded 165 results of QFT (3% positive, 87% negative,and 10% indeterminate results). During follow-up we identified 4 conversions of negative QFT to positivity (3%) and 4 reversions (4%). Patients with indeterminate results of QFT had significantly lower actual weight-for-height z score (P
Keywords
latent tuberculosisinterferon- release testsinfliximabinflammatory bowel diseaseimmunosuppressive therapy
The result's identifiers
Result code in IS VaVaI
Alternative codes found
RIV/00216208:11130/14:10292791 RIV/75010330:_____/14:00010730
Result on the web
DOI - Digital Object Identifier
Alternative languages
Result language
angličtina
Original language name
Disease Activity Is an Important Factor for Indeterminate Interferon-gamma Release Assay Results in Children With Inflammatory Bowel Disease
Original language description
Background:Interferon- release assay (IGRA) is widely used for screening of latent tuberculosis (TB) before and during biological therapy (BT). An indeterminate result of IGRA represents a limitation in the management of inflammatory bowel disease (IBD).Data on factors influencing IGRA results are scarce in children. The aim of the study was to identify factors influencing IGRA results in children with IBD.Methods:Seventy-two children with IBD (59 Crohn disease, 11 ulcerative colitis, 2 IBD-unclassified) indicated for BT were tested for TB infection (history, TB skin test, chest radiograph, IGRA; QuantiFERONTB Gold in tube [QFT]) and consecutively retested using QFT in 1-year intervals.Results:We recorded 165 results of QFT (3% positive, 87% negative,and 10% indeterminate results). During follow-up we identified 4 conversions of negative QFT to positivity (3%) and 4 reversions (4%). Patients with indeterminate results of QFT had significantly lower actual weight-for-height z score (P
Czech name
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Czech description
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Classification
Type
Jx - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FG - Paediatrics
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Pediatric Gastroenterology and Nutrition
ISSN
0277-2116
e-ISSN
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Volume of the periodical
58
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
5
Pages from-to
320-324
UT code for WoS article
000333297300014
EID of the result in the Scopus database
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Result type
Jx - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP
FG - Paediatrics
Year of implementation
2014