Cytokines, growth, and environment factors in bone marrow plasma of acute lymphoblastic leukemia pediatric patients

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F14%3A10292960" target="_blank" >RIV/00064203:_____/14:10292960 - isvavai.cz</a>

Alternative codes found

RIV/61388971:_____/14:00435970 RIV/00216208:11130/14:10292960

Result on the web

<a href="http://dx.doi.org/10.1684/ecn.2014.0348" target="_blank" >http://dx.doi.org/10.1684/ecn.2014.0348</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1684/ecn.2014.0348" target="_blank" >10.1684/ecn.2014.0348</a>

Result language

angličtina

Original language name

Cytokines, growth, and environment factors in bone marrow plasma of acute lymphoblastic leukemia pediatric patients

Original language description

Acute lymphoblastic leukemia (ALL) cells depend on the microenvironment of the host in vivo and do not survive in in vitro culture. Conversely, the suppression of non-malignant tissues is one of the leading characteristics of the course of ALL. Both thenon-malignant suppression and malignant cell survival may be partly affected by soluble factors within the bone marrow (BM) environment. Here, we aimed to identify proteins in BM plasma of children with ALL that may contribute to ALL aggressiveness and/or the microenvironment-mediated survival of ALL cells. LBMp (leukemic bone marrow plasma) at the time of ALL diagnosis was compared to control plasma of bone marrow (CBMp) or peripheral blood (CPBp) using a cytokine antibody array. The cytokine antibodyarray enabled simultaneous detection of 79 proteins per sample. Candidate proteins exhibiting significantly different profiles were further analyzed and confirmed by ELISA. mRNAexpression of one of the candidate proteins (TIMP1) was studi

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

<a href="/en/project/NR9531" target="_blank" >NR9531: Proteomic analysis of soluble proteins important in pediatric acute leukemia</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

European Cytokine Network

ISSN

1148-5493

e-ISSN

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Volume of the periodical

25

Issue of the periodical within the volume

1

Country of publishing house

FR - FRANCE

Number of pages

6

Pages from-to

8-13

UT code for WoS article

000341329400002

EID of the result in the Scopus database

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