All

What are you looking for?

All
Projects
Results
Organizations

Quick search

  • Projects supported by TA ČR
  • Excellent projects
  • Projects with the highest public support
  • Current projects

Smart search

  • That is how I find a specific +word
  • That is how I leave the -word out of the results
  • “That is how I can find the whole phrase”

Neuroblastoma mRNAs Predict Outcome in Children With Stage 4 Neuroblastoma: AEuropean HR-NBL1/SIOPEN Study

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F14%3A10292992" target="_blank" >RIV/00064203:_____/14:10292992 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11130/14:10292992

  • Result on the web

    <a href="http://dx.doi.org/10.1200/JCO.2013.53.3604" target="_blank" >http://dx.doi.org/10.1200/JCO.2013.53.3604</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1200/JCO.2013.53.3604" target="_blank" >10.1200/JCO.2013.53.3604</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Neuroblastoma mRNAs Predict Outcome in Children With Stage 4 Neuroblastoma: AEuropean HR-NBL1/SIOPEN Study

  • Original language description

    Purpose To evaluate the hypothesis that detection of neuroblastoma mRNAs by reverse transcriptase quantitative polymerase chain reaction (RTqPCR) in peripheral blood (PB) and bone marrow aspirates (BM) from children with stage 4 neuroblastoma are clinically useful biomarkers of risk. Methods RTqPCR for paired-like homeobox 2b (PHOX2B), tyrosine hydroxylase (TH), and doublecortin (DCX) mRNA in PB and BM of children enrolled onto the High-Risk Neuroblastoma Trial-1 of the European Society of Pediatric Oncology Neuroblastoma Group (HR-NBL1/SIOPEN) was performed at diagnosis and after induction therapy. Results High levels of TH, PHOX2B, or DCX mRNA in PB or BM at diagnosis strongly predicted for worse event-free survival (EFS) and overall survival (OS) ina cohort of 290 children. After induction therapy, high levels of these mRNAs predicted worse EFS and OS in BM but not in PB. Combinations of mRNAs in BM did not add to the predictive power of any single mRNA. However, in the original (n

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FD - Oncology and haematology

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2014

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Journal of Clinical Oncology

  • ISSN

    0732-183X

  • e-ISSN

  • Volume of the periodical

    32

  • Issue of the periodical within the volume

    10

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    10

  • Pages from-to

    1074-1083

  • UT code for WoS article

    000335138400017

  • EID of the result in the Scopus database