Post-mortem analysis of Candida albicans breakthrough infection during echinocandin treatment in haematopoietic stem cell transplant recipient

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F14%3A10293096" target="_blank" >RIV/00064203:_____/14:10293096 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/14:10293096

Result on the web

<a href="http://www.prolekare.cz/en/epidemiology-article/post-mortem-analysis-of-candida-albicans-breakthrough-infection-during-echinocandin-treatment-in-haematopoietic-stem-49183" target="_blank" >http://www.prolekare.cz/en/epidemiology-article/post-mortem-analysis-of-candida-albicans-breakthrough-infection-during-echinocandin-treatment-in-haematopoietic-stem-49183</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Post-mortem analysis of Candida albicans breakthrough infection during echinocandin treatment in haematopoietic stem cell transplant recipient

Original language description

We present case of a girl deceased due to Candida albicans breakthrough invasive infection during the echinocandin treatment after undergoing allogeneic haematopoietic stem cell transplant for relaps of acute myeloid leukaemia. Candida albicans generallysusceptible to all antifungal drugs wasn't considered for potential resistance and conventional blood culture positivity was too late to reveal the resistance to echinocandins. Due to severe organ toxicities (liver, kidneys) she received echinocandin asan antifungal prophylaxis, no change was made for the treatment of Candida albicans infection. Later, the molecular analysis proved the mutation S645P known as being responsible for the echinocandin resistance. The post mortem analysis of fungal burdenin autopsy samples showed very high levels of Candida DNA in gut, liver, spleen and kidneys.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EE - Microbiology, virology

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Epidemiologie, Mikrobiologie, Imunologie

ISSN

1210-7913

e-ISSN

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Volume of the periodical

63

Issue of the periodical within the volume

2

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

4

Pages from-to

121-124

UT code for WoS article

000343635300010

EID of the result in the Scopus database

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