DTI-MRI biomarkers in the search for normal pressure hydrocephalus aetiology: a review
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F15%3A10294510" target="_blank" >RIV/00064203:_____/15:10294510 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1007/s10143-014-0584-0" target="_blank" >http://dx.doi.org/10.1007/s10143-014-0584-0</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s10143-014-0584-0" target="_blank" >10.1007/s10143-014-0584-0</a>
Alternative languages
Result language
angličtina
Original language name
DTI-MRI biomarkers in the search for normal pressure hydrocephalus aetiology: a review
Original language description
Normal pressure hydrocephalus (NPH) is a clinical syndrome characterized by gait disturbances, urinary incontinence and dementia. Clinical presentation overlaps with Alzheimer disease (AD). Early recognition thus early intervention (shunting) is important for successful treatment, but lack of a diagnostic test with sufficient sensitivity and specificity complicates the diagnosis. We performed literature search and composed a structured review of imaging biomarkers of NPH. Morphometric studies are not sufficient to diagnose NPH. Hydrocephalus is a common finding in elderly people due to the symmetric brain atrophy and is even more pronounced in patients with AD. The key MRI biomarker seems to be diffusion tensor imaging (DTI). According to recent studies, the DTI analysis of the splenium corporis callosi, posterior limb of internal capsule, hippocampus and fornix combined with measurement of Evans index is a promising MRI biomarker of NPH and could be used for NPH diagnostics and in the differential diagnosis from AD and other dementias.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Neurosurgical Review
ISSN
0344-5607
e-ISSN
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Volume of the periodical
38
Issue of the periodical within the volume
2
Country of publishing house
DE - GERMANY
Number of pages
6
Pages from-to
239-244
UT code for WoS article
000351544400005
EID of the result in the Scopus database
2-s2.0-84925532991