Does Sex Affect Anticoagulant Use for Stroke Prevention in Nonvalvular Atrial Fibrillation? The Prospective Global Anticoagulant Registry in the FIELD-Atrial Fibrillation
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F15%3A10294523" target="_blank" >RIV/00064203:_____/15:10294523 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1161/CIRCOUTCOMES.114.001556" target="_blank" >http://dx.doi.org/10.1161/CIRCOUTCOMES.114.001556</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1161/CIRCOUTCOMES.114.001556" target="_blank" >10.1161/CIRCOUTCOMES.114.001556</a>
Alternative languages
Result language
angličtina
Original language name
Does Sex Affect Anticoagulant Use for Stroke Prevention in Nonvalvular Atrial Fibrillation? The Prospective Global Anticoagulant Registry in the FIELD-Atrial Fibrillation
Original language description
Background-Among patients with atrial fibrillation (AF), women are at higher risk of stroke than men. Using prospective cohort data from a large global population of patients with nonvalvular AF, we sought to identify any differences in the use of anticoagulants for stroke prevention in women and men. Methods and Results-This was a prospective multicenter observational registry with 858 randomly selected sites in 30 countries. A total of 17 184 patients with newly diagnosed ({= 6 weeks) nonvalvular AF and }= 1 additional investigator-defined stroke risk factor(s) were recruited (March 2010 to June 2013). The main outcome measure was the use of anticoagulants (vitamin K antagonists, factor Xa inhibitors, and direct thrombin inhibitors) for stroke prevention at AF diagnosis. Of 17 184 patients enrolled, 43.8% were women. More women than men were at moderate-to-high risk of stroke (CHADS(2) score }= 2: 65.1% versus 54.7%). Rates of anticoagulant use were not different overall (60.9% of men versus 60.8% of women) and in patients with a CHADS(2) score }= 2 (adjusted odds ratio for women versus men, 1.00; 95% confidence interval, 0.92-1.09). In patients at low risk (CHA(2)DS(2)-VASc of 0 in men and 1 in women), 41.8% of men and 41.1% of women received an anticoagulant. In patients at high risk (CHA(2)DS(2)-VASc score }= 2), 35.4% of men and 38.4% of women did not receive an anticoagulant. Conclusions-These contemporary global data show that anticoagulant use for stroke prevention is no different in men and women with nonvalvular AF. Thromboprophylaxis was, however, suboptimal in substantial proportions of men and women, with underuse in those at moderate-to-high risk of stroke and overuse in those at low risk.
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FA - Cardiovascular diseases including cardio-surgery
OECD FORD branch
—
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Circulation. Cardiovascular quality and outcomes [online]
ISSN
1941-7705
e-ISSN
—
Volume of the periodical
8
Issue of the periodical within the volume
2 / Supplement 1
Country of publishing house
HU - HUNGARY
Number of pages
9
Pages from-to
"S12"-"S20"
UT code for WoS article
000350767800003
EID of the result in the Scopus database
2-s2.0-84942123297