All

What are you looking for?

All
Projects
Results
Organizations

Quick search

  • Projects supported by TA ČR
  • Excellent projects
  • Projects with the highest public support
  • Current projects

Smart search

  • That is how I find a specific +word
  • That is how I leave the -word out of the results
  • “That is how I can find the whole phrase”

How and why to monitor Pseudomonas aeruginosa infections in the long term at a cystic fibrosis centre

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F16%3A10323762" target="_blank" >RIV/00064203:_____/16:10323762 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11130/16:10323762

  • Result on the web

    <a href="http://dx.doi.org/10.1016/j.jhin.2015.09.010" target="_blank" >http://dx.doi.org/10.1016/j.jhin.2015.09.010</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.jhin.2015.09.010" target="_blank" >10.1016/j.jhin.2015.09.010</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    How and why to monitor Pseudomonas aeruginosa infections in the long term at a cystic fibrosis centre

  • Original language description

    Background: Pseudomonas aeruginosa is a major cystic fibrosis (CF) pathogen causing chronic respiratory infections and posing a risk for cross-infection between patients with CF. Aim: To propose an algorithm for long-term surveillance of P. aeruginosa and assess its suitability for monitoring the epidemiological situation at a CF centre with approximately 300 patients. Methods: Over a nine-year period, over 300 P. aeruginosa isolates from 131 infected patients were tested by multi-locus sequence typing (MLST) and/or random amplified polymorphic DNA (RAPD) assay. Findings: MLST analysis led to the identification of 97 different sequence types which were distributed among 17 RAPD-generated (pseudo) clusters. This indicates that the easy-to-perform RAPD assay is only suitable for intra-individual, not interindividual, strain analyses. No epidemic strains were observed. Longitudinal analysis revealed that 110 of the 131 patients were infected with the same strain over the observation period, whereas 21 patients had a strain replacement or a new infection. Chronic infection was found in 99 of the 131 patients, and the remaining 32 patients met the criteria for intermittent infection (as defined by the Leeds criteria). Eighteen of the 32 patients (56%) with intermittent infection were infected with the same strain for up to nine years. Conclusion: The strain type only changed in 16% of 131 patients with chronic or intermittent infection. As many as 56% of patients considered to have intermittent infection were actually chronically infected with the same strain for many years.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    EE - Microbiology, virology

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/NT12405" target="_blank" >NT12405: Pathogenesis of fatal infection complication in patients with cystic fibrosis which is caused by Burkholderia cenocepacia</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2016

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Journal of Hospital Infection

  • ISSN

    0195-6701

  • e-ISSN

  • Volume of the periodical

    92

  • Issue of the periodical within the volume

    1

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    7

  • Pages from-to

    54-60

  • UT code for WoS article

    000367619800012

  • EID of the result in the Scopus database

    2-s2.0-84952981381