Promoter-Specific Hypomethylation Correlates with IL-1 beta Overexpression in Tuberous Sclerosis Complex (TSC)

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F16%3A10328128" target="_blank" >RIV/00064203:_____/16:10328128 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/16:10328128

Result on the web

<a href="http://dx.doi.org/10.1007/s12031-016-0750-7" target="_blank" >http://dx.doi.org/10.1007/s12031-016-0750-7</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s12031-016-0750-7" target="_blank" >10.1007/s12031-016-0750-7</a>

Result language

angličtina

Original language name

Promoter-Specific Hypomethylation Correlates with IL-1 beta Overexpression in Tuberous Sclerosis Complex (TSC)

Original language description

In tuberous sclerosis complex (TSC), overexpression of numerous genes associated with inflammation has been observed. Among different proinflammatory cytokines, interleukin-1 beta (IL-1 beta) has been shown to be significantly involved in epileptogenesis and maintenance of seizures. Recent evidence indicates that IL-1 beta gene expression can be regulated by DNA methylation of its promoter. In the present study, we hypothesized that hypomethylation in the promoter region of the IL-1 beta gene may underlie its overexpression observed in TSC brain tissue. Bisulfite sequencing was used to study the methylation status of the promoter region of the IL-1 beta gene in TSC and control samples. We identified hypomethylation in the promoter region of the IL-1 beta gene in TSC samples. IL-1 beta is overexpressed in tubers, and gene expression is correlated with promoter hypomethylation at CpG and non-CpG sites. Our results provide the first evidence of epigenetic modulation of the IL-1 beta signaling in TSC. Thus, strategies that target epigenetic alterations could offer new therapeutic avenues to control the persistent activation of interleukin-1 beta-mediated inflammatory signaling in TSC brain.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

—

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Molecular Neuroscience

ISSN

0895-8696

e-ISSN

—

Volume of the periodical

59

Issue of the periodical within the volume

4

Country of publishing house

US - UNITED STATES

Number of pages

7

Pages from-to

464-470

UT code for WoS article

000381161500004

EID of the result in the Scopus database

2-s2.0-84982835434