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Promoter-Specific Hypomethylation Correlates with IL-1 beta Overexpression in Tuberous Sclerosis Complex (TSC)

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F16%3A10328128" target="_blank" >RIV/00064203:_____/16:10328128 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11130/16:10328128

  • Result on the web

    <a href="http://dx.doi.org/10.1007/s12031-016-0750-7" target="_blank" >http://dx.doi.org/10.1007/s12031-016-0750-7</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1007/s12031-016-0750-7" target="_blank" >10.1007/s12031-016-0750-7</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Promoter-Specific Hypomethylation Correlates with IL-1 beta Overexpression in Tuberous Sclerosis Complex (TSC)

  • Original language description

    In tuberous sclerosis complex (TSC), overexpression of numerous genes associated with inflammation has been observed. Among different proinflammatory cytokines, interleukin-1 beta (IL-1 beta) has been shown to be significantly involved in epileptogenesis and maintenance of seizures. Recent evidence indicates that IL-1 beta gene expression can be regulated by DNA methylation of its promoter. In the present study, we hypothesized that hypomethylation in the promoter region of the IL-1 beta gene may underlie its overexpression observed in TSC brain tissue. Bisulfite sequencing was used to study the methylation status of the promoter region of the IL-1 beta gene in TSC and control samples. We identified hypomethylation in the promoter region of the IL-1 beta gene in TSC samples. IL-1 beta is overexpressed in tubers, and gene expression is correlated with promoter hypomethylation at CpG and non-CpG sites. Our results provide the first evidence of epigenetic modulation of the IL-1 beta signaling in TSC. Thus, strategies that target epigenetic alterations could offer new therapeutic avenues to control the persistent activation of interleukin-1 beta-mediated inflammatory signaling in TSC brain.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FH - Neurology, neuro-surgery, nuero-sciences

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2016

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Journal of Molecular Neuroscience

  • ISSN

    0895-8696

  • e-ISSN

  • Volume of the periodical

    59

  • Issue of the periodical within the volume

    4

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    7

  • Pages from-to

    464-470

  • UT code for WoS article

    000381161500004

  • EID of the result in the Scopus database

    2-s2.0-84982835434