Recurrent MET fusion genes represent a drug target in pediatric glioblastoma
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F16%3A10329620" target="_blank" >RIV/00064203:_____/16:10329620 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/16:10329620
Result on the web
<a href="http://dx.doi.org/10.1038/nm.4204" target="_blank" >http://dx.doi.org/10.1038/nm.4204</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/nm.4204" target="_blank" >10.1038/nm.4204</a>
Alternative languages
Result language
angličtina
Original language name
Recurrent MET fusion genes represent a drug target in pediatric glioblastoma
Original language description
Pediatric glioblastoma is one of the most common and most deadly brain tumors in childhood. Using an integrative genetic analysis of 53 pediatric glioblastomas and five in vitro model systems, we identified previously unidentified gene fusions involving the MET oncogene in similar to 10% of cases. These MET fusions activated mitogen-activated protein kinase (MAPK) signaling and, in cooperation with lesions compromising cell cycle regulation, induced aggressive glial tumors in vivo. MET inhibitors suppressed MET tumor growth in xenograft models. Finally, we treated a pediatric patient bearing a MET-fusion-expressing glioblastoma with the targeted inhibitor crizotinib. This therapy led to substantial tumor shrinkage and associated relief of symptoms, but new treatment-resistant lesions appeared, indicating that combination therapies are likely necessary to achieve a durable clinical response.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nature Medicine
ISSN
1078-8956
e-ISSN
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Volume of the periodical
22
Issue of the periodical within the volume
11
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
1314-1320
UT code for WoS article
000387302300024
EID of the result in the Scopus database
2-s2.0-84991702429