Zinc and zinc-containing biomolecules in childhood brain tumors
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F16%3A10332566" target="_blank" >RIV/00064203:_____/16:10332566 - isvavai.cz</a>
Alternative codes found
RIV/62156489:43210/16:43909786 RIV/00216208:11130/16:10332566 RIV/00216208:11310/16:10332566 RIV/00216305:26620/16:PU122173
Result on the web
<a href="http://dx.doi.org/10.1007/s00109-016-1454-8" target="_blank" >http://dx.doi.org/10.1007/s00109-016-1454-8</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00109-016-1454-8" target="_blank" >10.1007/s00109-016-1454-8</a>
Alternative languages
Result language
angličtina
Original language name
Zinc and zinc-containing biomolecules in childhood brain tumors
Original language description
Zinc ions are essential cofactors of a wide range of enzymes, transcription factors, and other regulatory proteins. Moreover, zinc is also involved in cellular signaling and enzymes inhibition. Zinc dysregulation, deficiency, over-supply, and imbalance in zinc ion transporters regulation are connected with various diseases including cancer. A zinc ion pool is maintained by two types of proteins: (i) zinc-binding proteins, which act as a buffer and intracellular donors of zinc and (ii) zinc transporters responsible for zinc fluxes into/from cells and organelles. The decreased serum zinc ion levels have been identified in patients suffering from various cancer diseases, including head and neck tumors and breast, prostate, liver, and lung cancer. On the contrary, increased zinc ion levels have been found in breast cancer and other malignant tissues. Zinc metalloproteomes of a majority of tumors including brain ones are still not yet fully understood. Current knowledge show that zinc ion levels and detection of certain zinc-containing proteins may be utilized for diagnostic and prognostic purposes. In addition, these proteins can also be promising therapeutic targets. The aim of the present work is an overview of the importance of zinc ions, zinc transporters, and zinc-containing proteins in brain tumors, which are, after leukemia, the second most common type of childhood cancer and the second leading cause of death in children after accidents.
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
—
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Molecular Medicine
ISSN
0946-2716
e-ISSN
—
Volume of the periodical
94
Issue of the periodical within the volume
11
Country of publishing house
DE - GERMANY
Number of pages
17
Pages from-to
1199-1215
UT code for WoS article
000386562500002
EID of the result in the Scopus database
2-s2.0-84988409812