Circulating heat shock protein mRNA profile in gestational hypertension, pre-eclampsia foetal growth restriction

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F16%3A10332826" target="_blank" >RIV/00064203:_____/16:10332826 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11120/16:43912560 RIV/00023698:_____/16:N0000024

Result on the web

<a href="http://dx.doi.org/10.4103/0971-5916.195037" target="_blank" >http://dx.doi.org/10.4103/0971-5916.195037</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4103/0971-5916.195037" target="_blank" >10.4103/0971-5916.195037</a>

Result language

angličtina

Original language name

Circulating heat shock protein mRNA profile in gestational hypertension, pre-eclampsia foetal growth restriction

Original language description

Background & objectives: Heat shock proteins (Hsp) are ubiquitously distributed phylogenetically conserved molecules that regulate cellular homeostasis and maintain the integrity and function of cellular proteins. Increased levels of Hsp in maternal circulation have been shown to be associated with increased risk of pregnancy related complications. The objective of this study was to explore extracellular Hsp mRNA levels in maternal circulation and quantified Hsp27, Hsp60, Hsp70, Hsp90 and Hsp70 binding protein 1 (HspBP1) mRNAs in maternal plasma samples using real-time reverse-transcriptase polymerase chain reaction. Methods: Pregnancies with gestational hypertension (GH) (n = 33), pre-eclampsia (PE) with or without foetal growth restriction (FGR) (n = 78) and FGR (n = 25) were involved in the study. Hsp gene expression was analysed in relation to the severity of the disease with respect to the degree of clinical signs, requirements for the delivery and Doppler ultrasound parameters. Results: Upregulation of Hsp70 was observed in patients with mild and severe PE (P = 0.004 and P = 0.005, respectively) and in pregnancies complicated with PE delivering before and after 34 wk of gestation regardless of the degree of clinical signs (P = 0.015 and P = 0.009, respectively). No difference in the expression of other Hsp genes among the studied groups was observed. No association between Hsp gene expression and Doppler ultrasonography parameters was found. Interpretation conclusions: These data support that maternal circulation can reflect both maternal and foetal pathologic conditions. Hsp70 represents the sole plasmatic marker, and increased Hsp70 mRNA levels reflect maternal and placental stress response to pregnancy-related complications such as GH and PE, irrespective of the severity of the disease.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EC - Immunology

OECD FORD branch

—

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Indian Journal of Medical Research

ISSN

0971-5916

e-ISSN

—

Volume of the periodical

144

Issue of the periodical within the volume

August

Country of publishing house

IN - INDIA

Number of pages

9

Pages from-to

229-237

UT code for WoS article

000390593900011

EID of the result in the Scopus database

2-s2.0-85006054181