Ictal SPECT is useful in localizing the epileptogenic zone in infants with cortical dysplasia

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F16%3A10334481" target="_blank" >RIV/00064203:_____/16:10334481 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/16:10334481

Result on the web

<a href="http://dx.doi.org/10.1684/epd.2016.0870" target="_blank" >http://dx.doi.org/10.1684/epd.2016.0870</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1684/epd.2016.0870" target="_blank" >10.1684/epd.2016.0870</a>

Result language

angličtina

Original language name

Ictal SPECT is useful in localizing the epileptogenic zone in infants with cortical dysplasia

Original language description

AIMS: To assess the localizing value of ictal SPECT in very young epilepsy surgery candidates when cerebral haemodynamic responses are known to be immature. METHODS: We retrospectively studied 13 infants with intractable focal epilepsy caused by focal cortical dysplasia (FCD). Completeness of resection of the (1) ictal SPECT hyperperfusion zone and (2) cerebral cortex with prominent ictal and interictal abnormalities on intracranial EEG (ECoG or long-term invasive monitoring) and the MRI lesion, when present, were correlated with postoperative seizure outcome. RESULTS: All five patients with complete resection of the ictal SPECT hyperperfusion zone were seizure-free compared to only one of eight patients with incomplete or no excision of hyperperfusion zones (p=0.00843). Similar results were noted for the MRI/iEEG-defined epileptogenic region; five of six patients with complete removal were seizure-free, whereas only one of seven incompletely resected patients was seizure-free (p=0.02914). All four patients who underwent complete resection of both regions were seizure-free compared to none of the six with incomplete resection (p=0.01179). CONCLUSION: Despite age-related differences in cerebral perfusion, ictal SPECT provides useful localization data in infants with FCD. Complete resection of the hyperperfused regions is a strong predictor of favourable outcome. The added information may alleviate the need for invasive EEG evaluations in some patients.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

—

Project

<a href="/en/project/NT13357" target="_blank" >NT13357: Defining epileptogenicity markers in tuberous sclerosis and improvement in epilepsy surgery</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Epileptic Disorders

ISSN

1294-9361

e-ISSN

—

Volume of the periodical

18

Issue of the periodical within the volume

4

Country of publishing house

FR - FRANCE

Number of pages

7

Pages from-to

384-390

UT code for WoS article

000392460700005

EID of the result in the Scopus database

2-s2.0-85010465480