Serum Creatinine Levels May Not Necessarily Reflect a True Renal Function to Adjust Amikacin Dose in Paraplegic Patient: A Case Report and Literature Review

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F16%3A10336302" target="_blank" >RIV/00064203:_____/16:10336302 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/16:10336302

Result on the web

<a href="http://dx.doi.org/10.4172/2157-7609.1000209" target="_blank" >http://dx.doi.org/10.4172/2157-7609.1000209</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4172/2157-7609.1000209" target="_blank" >10.4172/2157-7609.1000209</a>

Result language

angličtina

Original language name

Serum Creatinine Levels May Not Necessarily Reflect a True Renal Function to Adjust Amikacin Dose in Paraplegic Patient: A Case Report and Literature Review

Original language description

To estimate glomerular filtration rate as an indicator of kidney function, clearance of endogenous creatinine is usually used despite its unreliability due to influence of several factors including age, gender, muscle mass and interferences within methods. Although there is emergence of better markers like serum cystatin-C, creatinine clearance continues to be used routinely as a marker of renal function to date. In the present case study we describe only slightly elevation of serum creatinine associated with high serum drug concentration 27 mg/L "trough" and 41 mg/L "peak", respectively in a paraplegic patient treated with initially reduced dose (500 mg/day) of an aminoglycoside antibacterial drug (amikacin). The relatively little increment of serum creatinine in this case might be related to underlying pathology resulting in low production of creatinine, which does not essentially reflect the true renal function. Methodological challenges during GFR estimation and risk of renal impairment in Spinal Cord Injury (SCI) patents are also discussed in context with literature review.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Drug Metabolism &amp; Toxicology

ISSN

2157-7609

e-ISSN

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Volume of the periodical

2

Issue of the periodical within the volume

7

Country of publishing house

US - UNITED STATES

Number of pages

4

Pages from-to

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UT code for WoS article

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EID of the result in the Scopus database

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