Tachycardia-Induced Cardiomyopathy As a Chronic Heart Failure Model in Swine
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F18%3A10375354" target="_blank" >RIV/00064203:_____/18:10375354 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/18:10375354 RIV/00023884:_____/18:00007926
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=5gXm_K7VnL" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=5gXm_K7VnL</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3791/57030" target="_blank" >10.3791/57030</a>
Alternative languages
Result language
angličtina
Original language name
Tachycardia-Induced Cardiomyopathy As a Chronic Heart Failure Model in Swine
Original language description
A stable and reliable model of chronic heart failure is required for many experiments to understand hemodynamics or to test effects of new treatment methods. Here, we present such a model by tachycardia-induced cardiomyopathy, which can be produced by rapid cardiac pacing in swine. A single pacing lead is introduced transvenously into fully anaesthetized healthy swine, to the apex of the right ventricle, and fixated. Its other end is then tunneled dorsally to the paravertebral region. There, it is connected to an in-house modified heart pacemaker unit that is then implanted in a subcutaneous pocket. After 4 - 8 weeks of rapid ventricular pacing at rates of 200 - 240 beats/min, physical examination revealed signs of severe heart failure tachypnea, spontaneous sinus tachycardia, and fatigue. Echocardiography and X-ray showed dilation of all heart chambers, effusions, and severe systolic dysfunction. These findings correspond well to decompensated dilated cardiomyopathy and are also preserved after the cessation of pacing. This model of tachycardia-induced cardiomyopathy can be used for studying the pathophysiology of progressive chronic heart failure, especially hemodynamic changes caused by new treatment modalities like mechanical circulatory supports. This methodology is easy to perform and the results are robust and reproducible.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30105 - Physiology (including cytology)
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
JoVE: Journal of Visualized Experiments
ISSN
1940-087X
e-ISSN
—
Volume of the periodical
February
Issue of the periodical within the volume
132
Country of publishing house
US - UNITED STATES
Number of pages
11
Pages from-to
e57030
UT code for WoS article
000426453400066
EID of the result in the Scopus database
2-s2.0-85042435453