Intradialytic alkalization affects calcium balance and PTH level
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F19%3A10394154" target="_blank" >RIV/00064203:_____/19:10394154 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/19:10394154
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=J2ttmga9HG" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=J2ttmga9HG</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/sdi.12746" target="_blank" >10.1111/sdi.12746</a>
Alternative languages
Result language
angličtina
Original language name
Intradialytic alkalization affects calcium balance and PTH level
Original language description
We have read with great interest the excellent review of Basile et al1 and would like to add two more potential adverse effects of high dialysate bicarbonsate. We have recently published a pilot study evaluating the influence of dialysate bicarbonate concentration on intradialytic calcium balance and plasma PTH level changes in chronic dialysis patients. We found that dialysate bicarbonate influences plasma calcium, calcium balance, and intradialytic PTH levels. A higher dialysate bicarbonate decreases intradialytic losses of calcium and can result in actual calcium gains. These effects are primarily a result of the influence of alkalinization on plasma ionized calcium. As a patient is alkalized, plasma ionized calcium decreases which increases the diffusive gradient of ionized calcium from dialysate to the patient during the treatment. At the same time, intradialytic alkalinization leads to increased PTH secretion, also a consequence of the decreased plasma ionized calcium associated with the increased blood pH
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30217 - Urology and nephrology
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Seminars in Dialysis
ISSN
0894-0959
e-ISSN
—
Volume of the periodical
32
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
2
Pages from-to
85-86
UT code for WoS article
000455019600012
EID of the result in the Scopus database
2-s2.0-85054765505