Epidural Analgesia With Sufentanil in Relation to OPRM1 and ABCB1 Polymorphisms

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F19%3A10401406" target="_blank" >RIV/00064203:_____/19:10401406 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/19:10401406 RIV/00064165:_____/19:10401406

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=8CXUBfSO.7" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=8CXUBfSO.7</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.33549/physiolres.934325" target="_blank" >10.33549/physiolres.934325</a>

Result language

angličtina

Original language name

Epidural Analgesia With Sufentanil in Relation to OPRM1 and ABCB1 Polymorphisms

Original language description

The aim of this study was to evaluate the association between OPRM1 and ABCB1 polymorphisms on pain relief with epidural sufentanil in 69 patients after rectosigma resection for cancer. The median number of injections (SD) 2.31 (1.36), IQR=1, required by 118AA subjects was significantly lower in comparison with 118AG group 5.25 (3.13), IQR=6.5, (X-2=9.75, p=0.001); correspondingly median drug consumption of 1.16 (0.79), IQR=1.083, defined daily doses (DDD) was significantly less in the 118AA group in comparison with 2.14 (1.17), IQR=2.23, DDD in 118AG subjects, (X-2=7.00, p=0.008). Opioid-induced adverse effects were observed in 15 % and 33 % of patients in 118AA and 118AGgroups, respectively (X-2=8.16, p=0.004). The median number of injections (SD) required by women and men was 3.30 (2.16), IQR=2, and 2.80 (1.59), IQR=1, respectively (X-2=6.25, p=0.012). Opioid-induced adverse effects were observed in 26 % and 12 % of women and men, respectively (X-2=5.49, p=0.011). Heterozygotes of OPRM1 polymorphism and women were more difficult to treat subpopulations that required higher doses of rescue analgesic medication and suffered more adverse effects.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30212 - Surgery

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Physiological Research

ISSN

0862-8408

e-ISSN

—

Volume of the periodical

68

Issue of the periodical within the volume

Suplement 1

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

6

Pages from-to

"S59"-"S64"

UT code for WoS article

000499085100007

EID of the result in the Scopus database

2-s2.0-85075419481