Comparison of interim PET response to second-line vs. to first-line treatment in classical Hodgkin lymphoma - contribution to the development of response criteria for relapsed or progressive disease

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F21%3A10413221" target="_blank" >RIV/00064203:_____/21:10413221 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/21:10413221
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=w2Tvru4HUL" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=w2Tvru4HUL</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2967/jnumed.120.247924" target="_blank" >10.2967/jnumed.120.247924</a>

Result language
angličtina
Original language name
Comparison of interim PET response to second-line vs. to first-line treatment in classical Hodgkin lymphoma - contribution to the development of response criteria for relapsed or progressive disease
Original language description
Rationale: In first-line treatment of Hodgkin lymphoma (HL) Deauville scores 1-3 define complete metabolic remission. Interim FDG-PET is also used for relapse treatment adaptation, however PET-response criteria are not validated for relapse treatment. Methods: We performed a pairwise comparative analysis of early treatment response to first-line and to second-line treatment in 127 patients with classical Hodgkin lymphoma who experienced relapse. Patients participated in the prospective, multicenter EuroNet-PHL-C1 study. Residual uptake was measured retrospectively using the qPET method, a validated semiautomatic quantitative extension of the Deauville score. Empirical cumulative distribution functions (ECDF) of the qPET values were used to systematically analyze the response to first-line and second-line treatment. Results and Conclusion: Individual patients responded variably to first-line and second line treatment. However, the ECDF of the qPET values from all patients were nearly superimposable. This supports that first-line and second-line treatment in HL do not require different response criteria.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30205 - Hematology

Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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